TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.4.7.1
The mechanically gated hearing and balance ion channel in sensory hair cells of the vertebrate inner ear, NompC (Sidi et al., 2003)

Accession Number:Q7T1G6
Protein Name:Ion channel NompC
Length:1614
Molecular Weight:175800.00
Species:Danio rerio (Zebrafish) (Brachydanio rerio). [7955]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

eggNOG: veNOG23528
HEGENOM: HBG378504
RefSeq: NP_899192.1   
Entrez Gene ID: 368273   
Pfam: PF00023    PF00520   
KEGG: dre:368273   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005262 F:calcium channel activity
GO:0006816 P:calcium ion transport
GO:0050910 P:detection of mechanical stimulus involved i...
GO:0055085 P:transmembrane transport

References (1)

[1] “NompC TRP channel required for vertebrate sensory hair cell mechanotransduction.”  Sidi S.et.al.   12805553

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSESSCVSGA PQRLVPLALR GEWMALEQKI KTLERGDPDI LQCDEESGMS LLMLAVRESR 
61:	LSVLDRLLEL GANPSDKTKD GRSALHIAAA HSKDEIVKLL VRKTDPNSPA GPNDQLPLHY 
121:	AASRSTGGLA VVQTLLKFSS KDARLTPDKN GCLPLLLAAE AGNVGIVREL LSSQSEPQIR 
181:	AAKTANGDTA LHICCRRRDV EMAKILVEFG ANPDSQNDEG QTPLHIAAHE GDENMLKFLY 
241:	LCKANANISD KMDRSPLHIA AERGHTNVVE ILTEKFRSCV LARTKDGNTL LHIASQCGHP 
301:	TTALSFLRKG VPLHMPNKSG AVCLHAAAKR GHTAVVKALL QKGAHVDAAA RDGQTALHIA 
361:	VENCRPQVVQ MLLGFGAHVQ LRGGKAQETP LHISARVKEG ERAAEMLLKS GAEVNAEQEN 
421:	GETALHVAAR HGSLQMIRAL IQEGGDPRWR SRVGESPLHV AVRHCHAHVV QEILTFLTNE 
481:	KSRRDAELCV CEGNQDGETA LHLAAELRTD ALHQPEEDIT IIQILMEHQA DITAVTRQTG 
541:	ETPLHYSARV GNTAVLQEML RNVPTNQIQT AINKHSKNGW SPLLLAADQG HTEVVKILLQ 
601:	NNARVDVFDE EGKAAIHLAA QRGHQDIVDV LLSQKAFVNA KTKQGLTPLH LSAQNGSARL 
661:	VRLLVENHQA SVDALSLRKQ TPLHLAAMSG QLDVCSSLLN LRADITATDS RGQTPLHLAA 
721:	ESDHSEVVKL FLRLRPELST LANEDGSTCT HIAAAKGSVS VIRELLMFNQ GGVGTLNHKA 
781:	HGLCPLHLAA AGGHAEVVKV LLEAGASVTE EDAEGMTAVH LAAKHGHTHI LEVLRGSVPL 
841:	KIQSSKTGFT ALHVAASFGQ MNFVREILTK VPATIRSEFP TISGKDDIKR QQPLAESGFT 
901:	PLHLASQSGH ESVVRLLLNC PGVQADAETN IQGSSPLHLA AQSGHTAVVG LLLSRSSSLL 
961:	HQADRRGRSA LHLAAAHGHV DMVRVLLGQG AEINHTDMSG WTALHYAAEA GCLEVLLFLV 
1021:	ESGASACAEC HGGRTPLQYA AQQNHESAVI FLLRREKNTL RLLDDKKFIF NLMVCGRMND 
1081:	NLSLEELVLH TSAPLDTAVR LSRALTLCAL REKERSVDLQ AAAHHCELMA SDLLSLSASA 
1141:	GGQGAGAGPI LRALDHRGLS VLDCLIEGRQ KGVVSQPAVQ TYLTEVWCGG LQWDSWKILL 
1201:	LFCCLLLCPP LWLLLALPLT HSFNTIPIVK FMSHLVSHIF LLTLFILTIV YPPVSPLSQA 
1261:	RLMPSWSECL LLIWLCGMLV SELTFPGERT GLAWIRLLLL GFSAAALLCH LLAVFTQWWP 
1321:	PTHLHCLFAR NVLLAVAMTL GFIQLLEFLT FHHLFGPWAI IIRDLIKDLC RFAVILMLFH 
1381:	TAFTLSLTAL CQPLYPQEQH NTTTEVTVPG PLNMSVLLFF ALFGLTEPDK IPDVDRSPPA 
1441:	TAVLAKMVFG VYLVVTFIVL INLLIAMMSD TYQRIQAQSD TEWKFGRAVL IRDMSRKSGI 
1501:	PSPFNLFTNL FYSVKVVCKR AGKMCSSESR DVMNEDEDAE GLSESRSLDL LSQASVSGIR 
1561:	GNKRTQILPE GGQISLAHSG GHVRVENVAD WPSVVQQFLS QRRQRDRSTA ERDE