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1.A.4.7.3
The pore forming subunit, Trp-4, a mechanosensitive cation/Ca2+ channel. Present in ciliated mechanosensitive neurons; Activation and latency occur in the microsecond range. trp-4 mutations alter ion selectivity (Kang et al., 2010; Xiao and Xu 2009). 

Accession Number:Q9GRV5
Protein Name:Protein Y71A12B.4, partially confirmed by transcript evidence
Length:1924
Molecular Weight:212903.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:9
Substrate Ca2+

Cross database links:

eggNOG: meNOG05661
HEGENOM: HBG378504
Entrez Gene ID: 190574   
Pfam: PF00023    PF00520   
KEGG: cel:Y71A12B.4   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005262 F:calcium channel activity

References (1)

[1] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MDSPRGGILG RALREASQST RQENDVDMDQ VPVRQMNRDY GGSRRTQMNP HTSQPGPSHV 
61:	SIVNVPERGG PTSSTSTTHE TEHTAHRTES GRFIRRRRQS REVTTTTTRP YDPAPPTQTR 
121:	TSSGSTVNGW GENRPKSADE EIKRRRRSGG GILSRGLREM NKMVEELEQA SEEPSTRKGI 
181:	LGTALKDMEG TTYQKIYRKR EETPKRSRSF DDQEMSNRVG MIEHLLRDKD PLELQQLGLT 
241:	DLLTTDTIPT DRPPLRRSST HLQIGKNSRI IFVPKQPSRD SVTPPDRLLG KPLFRESLTS 
301:	HASSHEEMSS EDLAMADPQT KILYFAKRDE WANVESEIET IKRSDFSMAD NHGFTAFLLA 
361:	VKAGKDQIVD KMIRKGARVD YSTKDGRNAT HIAAMYSGVE TLELILKRYS ELLRKGAGPK 
421:	KQLAIHVACE RKSKKAFPIV KRILEDTDQR MAEDGDGSLP IHLAFKFGNV NIVELLLSGP 
481:	SDEQTRKADG NGDTLLHLAA RSGNIEAVRT AIAAGCDNAN VQNRVGRTPL HEVAEVGDQN 
541:	MLKIMFKLRA DANIHDKEDK TPVHVAAERG DTSMVESLID KFGGSIRART RDGSTLLHIA 
601:	ACSGHTSTAL AFLKRGVPLF MPNKKGALGL HSAAAAGFND VVKMLIARGT NVDVRTRDNY 
661:	TALHVAVQSG KASVVETLLG SGADIHVKGG ELGQTALHIA ASLNGAESRD CAMMLLKSGG 
721:	QPDVAQMDGE TCLHIAARSG NKDIMRLLLD ENADSKISSK IGETPLQVAA KSCNFEAASM 
781:	ILKHLSEVLT QEQLKEHVNH RTNDGFTALH YAAEIEQRQL HFPGEDAKLV NLLIDYGGMV 
841:	EMPSLNANET AMHMAARSGN QAVLLAMVNK IGAGAVQIVQ NKQSKNGWSP LLEACARGHS 
901:	GVANILLKHH ARIDVFDEMG RTALHLAAFN GHLSLVHLLL QHKAFVNSKS KTGEAPLHLA 
961:	AQHGHVKVVN VLVQDHGAAL EAITLDNQTA LHFAAKFGQL AVSQTLLALG ANPNARDDKG 
1021:	QTPLHLAAEN DFPDVVKLFL KMRNNNRSVL TAIDHNGFTC AHIAAMKGSL AVVRELMMID 
1081:	KPMVIQAKTK TLEATTLHMA AAGGHANIVK ILLENGANAE DENSHGMTAL HLGAKNGFIS 
1141:	ILEAFDKILW KRCSRKTGLN ALHIAAFYGN SDFVNEMLKH VQATVRSEPP IYNHHVNKEF 
1201:	STEYGFTPLH LAAQSGHDSL VRMLLNQGVQ VDATSTTMNV IPLHLAAQQG HIAVVGMLLS 
1261:	RSTQQQHAKD WRGRTPLHLA AQNGHYEMVS LLIAQGSNIN VMDQNGWTGL HFATRAGHLS 
1321:	VVKLFIDSSA DPLAETKEGK VPLCFAAAHN HIECLRFLLK QKHDTHQLME DRKFIFDLMV 
1381:	CGKTNDNEPL QEFILQSPAP IETAVKLSAL YRDMSEKEKE RAKDLLNVAV FSENMAVELL 
1441:	GITATEYNAA LLLKAKDNRG RPLLDVLIEN EQKEVVSYAS VQRYLTEVWT ARVDWSFGKF 
1501:	VAFSLFVLIC PPAWFYFSLP LDSRIGRAPI IKFVCHIVSH VYFTILLTIV VLNITHKMYE 
1561:	VTSVVPNPVE WLLLLWLSGN LVSELSTVGG GSGLGIVKVL ILVLSAMAIA VHVLAFLLPA 
1621:	VFLTHLDNDE KLHFARTMLY LKNQLFAFAL LFAFVEYLDF LTVHHLFGPW AIIIRDLMYD 
1681:	LARFLVILML FVAGFTLHVT SIFQPAYQPV DEDSAELMRL ASPSQTLEML FFSLFGLVEP 
1741:	DSMPPLHLVP DFAKIILKLL FGIYMMVTLI VLINLLIAMM SDTYQRIQAQ SDKEWKFGRA 
1801:	ILIRQMNKKS ATPSPINMLT KLIIVLRVAW RNRLRCMTRK AQDDLRFEEN IDAFSMGGGQ 
1861:	QGRQSPTNEG REGQQELGNS ADWNIETVID WRKIVSMYYQ ANGKLTDGRT KEDVDLAMAV 
1921:	PTSF