TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.4.9.2
TRP-like ion channel PKD2 (Polycystic kidney disease-related ion channel 2).  Regulates cytoplasmic calcium ion concentrations (Ma et al. 2011).

Accession Number:Q09917
Protein Name:TRP-like ion channel pkd2
Length:710
Molecular Weight:79989.00
Species:Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [284812]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate inorganic cations, Ca2+

Cross database links:

eggNOG: NOG74375
Entrez Gene ID: 2541613   
Pfam: PF06011   
KEGG: spo:SPAC1F7.03   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0030173 C:integral to Golgi membrane
GO:0005887 C:integral to plasma membrane
GO:0031520 C:plasma membrane of cell tip
GO:0005262 F:calcium channel activity
GO:0070509 P:calcium ion import
GO:0071433 P:cell wall repair
GO:0006874 P:cellular calcium ion homeostasis
GO:0090002 P:establishment of protein localization in plasma membrane
GO:0009272 P:fungal-type cell wall biogenesis
GO:0031505 P:fungal-type cell wall organization
GO:0017157 P:regulation of exocytosis
GO:0032995 P:regulation of fungal-type cell wall biogenesis
GO:0033157 P:regulation of intracellular protein transport

References (3)

[1] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360
[2] “A microbial TRP-like polycystic-kidney-disease-related ion channel gene.”  Palmer C.P.et.al.   15537393
[3] “Phosphoproteome analysis of fission yeast.”  Wilson-Grady J.T.et.al.   18257517

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MRLWRSPLLL LVVVVELFSW ADALTRFISA DSLSTCMTDS QLSASKLYAS YFPDNQSVAF 
61:	DISIQSLVST NVSIDVDISA YGIEIKKVID PCDMEISGFC PMQTGNIALS GSHTLTGEAL 
121:	SILDSIPSIA YTVPDLDAVV TINIYESDTN TQLACVRTTV QNGRSVYHRA VYWVMCMVIG 
181:	IPLLIFLLIS PVLQTPALWE IVETMITLFQ FAQIQALYSM MATSLPAIIY SWGRNFMWSM 
241:	GIIRIGFMQD VFTWYVKSTG GTPSTLVDLG IHANVALAKR GIDLGSLAKR ATTTVTTSTS 
301:	DSITLRGIKR ISYMMGIETT NFFATGFSFF IILLFFSLLV AMASRFIVEM VLLASRNQAL 
361:	KKQRIRLYWK SISKGFFYRV IFVGFTQMSV LSMWEIYTRD SSALAFLSMY VIVDMAVLLC 
421:	YAFVRTIQII RKTGPYSHPD VLYNLYSDTQ HLMRWGFMYV QLDVRFFYFT FPLLLITLVR 
481:	SMFIGFGQGS PKVQGCAMFG ISVVVFALMV ILRPYATKHM NTLHIGVALM NLISGSFILV 
541:	MCQAFYVEEL ARQVIGIIFF ALNAITMLLL ILGIFIRTLI VLFRKSGHGT YYRILDDQSE 
601:	KATSYNKSIK DMSSSDMAFS DPAYSGTTLR SSVDLNTPEY PFSNRNDSDS TFTNNKYVSP 
661:	WDAIEEASYA NLRGNTDVEQ PFMESDYTRI SENNNNAERR RKPLPNNAFR