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1.A.46.1.2
Bestrophin-2 anion channel (PNO3-/PCl- = 2.7) (Sun et al., 2002).  The mouse orthologue is swell-insensitive, but the first 64 aas of Bestrophin 1 of Drosophila melanogaster allowed it to mediate cell swelling in response to hypo-osmotic stress (Stotz and Clapham 2012).

Accession Number:Q8NFU1
Protein Name:Bestrophin-2 aka VMD2L1
Length:509
Molecular Weight:57139.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate nitrate, Cl-

Cross database links:

Genevestigator: Q8NFU1
eggNOG: prNOG14586
HEGENOM: HBG385747
RefSeq: NP_060152.2   
Entrez Gene ID: 54831   
Pfam: PF01062   
OMIM: 607335  gene
KEGG: hsa:54831   

Gene Ontology

GO:0034707 C:chloride channel complex
GO:0005929 C:cilium
GO:0005886 C:plasma membrane
GO:0005254 F:chloride channel activity
GO:0006811 P:ion transport
GO:0051899 P:membrane depolarization
GO:0007608 P:sensory perception of smell

References (5)

[1] “Three novel human VMD2-like genes are members of the evolutionary highly conserved RFP-TM family.”  Stoehr H.et.al.   12032738
[2] “Structure-function analysis of the bestrophin family of anion channels.”  Tsunenari T.et.al.   12907679
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The vitelliform macular dystrophy protein defines a new family of chloride channels.”  Sun H.et.al.   11904445
[5] “Bestrophin Cl- channels are highly permeable to HCO3-.”  Qu Z.et.al.   18400985

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTVTYTARVA NARFGGFSQL LLLWRGSIYK LLWRELLCFL GFYMALSAAY RFVLTEGQKR 
61:	YFEKLVIYCD QYASLIPVSF VLGFYVTLVV NRWWSQYLCM PLPDALMCVV AGTVHGRDDR 
121:	GRLYRRTLMR YAGLSAVLIL RSVSTAVFKR FPTIDHVVEA GFMTREERKK FENLNSSYNK 
181:	YWVPCVWFSN LAAQARREGR IRDNSALKLL LEELNVFRGK CGMLFHYDWI SVPLVYTQVV 
241:	TIALYSYFLA CLIGRQFLDP AQGYKDHDLD LCVPIFTLLQ FFFYAGWLKV AEQLINPFGE 
301:	DDDDFETNFL IDRNFQVSML AVDEMYDDLA VLEKDLYWDA AEARAPYTAA TVFQLRQPSF 
361:	QGSTFDITLA KEDMQFQRLD GLDGPMGEAP GDFLQRLLPA GAGMVAGGPL GRRLSFLLRK 
421:	NSCVSEASTG ASCSCAVVPE GAAPECSCGD PLLDPGLPEP EAPPPAGPEP LTLIPGPVEP 
481:	FSIVTMPGPR GPAPPWLPSP IGEEEENLA