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1.A.46.1.4
Bestrophin 3 vitelliform macular dystrophy 2-like protein 3 (possesses a C-terminal motif blocking its own channel activity (Qu et al., 2006).  Ca2+ activates anion flux with SCN->I->Cl-.

Accession Number:Q6H1V1
Protein Name:Bestrophin-3 aka Best3
Length:669
Molecular Weight:76431.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate SCN-, I-, Cl-

Cross database links:

Genevestigator: Q6H1V1
eggNOG: roNOG08948
HEGENOM: HBG127260
RefSeq: NP_001007584.1   
Entrez Gene ID: 382427   
Pfam: PF01062   
KEGG: mmu:382427   

Gene Ontology

GO:0034707 C:chloride channel complex
GO:0005886 C:plasma membrane
GO:0005254 F:chloride channel activity
GO:0015698 P:inorganic anion transport
GO:0043271 P:negative regulation of ion transport

References (1)

[1] “Cloning and characterization of the murine Vmd2 RFP-TM gene family.”  Kraemer F.et.al.   15218265

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTVTYSSKVA NATFFGFHRL LLKWRGSIYK LLYREFIVFA VLYTAISLVY RLLLTGAQKR 
61:	YFEKLSIYCD RYAEQIPVTF VLGFYVTLVV NRWWNQFVNL PWPDRLMLLI SSSVHGSDQH 
121:	GRLLRRTLMR YVNLTSLLIF RSVSTAVYKR FPTMDHVVEA GFMTADERKL FDHLKSPHLK 
181:	YWVPFIWFGN LATKARNEGR IRDSVDLQSL MTEMNRYRSW CSLLFGYDWV GIPLVYTQVV 
241:	TLAVYTFFFA CLIGRQFLDP TKGYVGHDLD LYVPIFTLLQ FFFYAGWLKV AEQLINPFGE 
301:	DDDDFETNWC IDRNLQVSLL AVDEMHMSLP KMKKDIYWDD SAARPPYTLA AADYCIPSFL 
361:	GSTIQMGLSG SNFPAEDWLW NYEKHGNRHS VMRRVKRFLS THEHPGSPRR RRSFGRQASD 
421:	SSMFLPPSPA RDLLDVPSRN PHRGSPTRKQ SRSQEGSPKL HSSMGELSTI RETSRTSTLQ 
481:	SLSPQSSVRS SPTKMPQVPE VLITAAEAPA FSADSHQHDS TTSILSLEFT GVQPSGTEQQ 
541:	VEPSGTPPGD PNPQTTSAST ERDLFKFEED LEDDRFPKRW SLPEFLESRH TSLGNLGPDP 
601:	VSPRDALLLP DTETPSETNG IHPGAGSALA PDILYLMESL DKETDILEFN NEHTGESPKG 
661:	TPQRPRTWF