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1.A.46.1.5
Bestrophin1, isoform B.  Identified as the Cl- (swell) channel that allows swelling in hypo-osmotic solutions (Stotz and Clapham 2012).  Its N-terminal 64 aas are essential for swell activation. 

Accession Number:B7Z0U6
Protein Name:Bestrophin 1, isoform B
Length:769
Molecular Weight:84350.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:5
Substrate Cl-

Cross database links:

Entrez Gene ID: 53431   
Pfam: PF01062   
KEGG: dme:Dmel_CG6264   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0072320 F:volume-sensitive chloride channel activity
GO:0006884 P:cell volume homeostasis

References (2)

[1] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[2] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTITYTGEVA TCRGFGCFLK LLLRWRGSIY KLVWLDLLAF LTIYYAINMV YRFGLNPAQK 
61:	ETFEAIVQYC DSYRELIPLS FVLGFYVSIV MTRWWNQYTS IPWPDPIAVF VSSNVHGQDE 
121:	RGRMMRRTIM RYVCLCLTMV LANVSPRVKK RFPGLNNLVE AGLLNDNEKT IIETMNKAFP 
181:	RPSKHWLPIV WAASIITRAR KEGRIRDDFA VKTIIDELNK FRGQCGLLIS YDTISVPLVY 
241:	TQVVTLAVYS YFLTCCMGQQ WTDGKVVGNT TYLNKVDLYF PVFTTLQFFF YMGWLKVAES 
301:	LINPFGEDDD DFEVNWMVDR NLQVSYLIVD EMHHDHPELL KDQYWDEVFP NELPYTIAAE 
361:	RFRENHPEPS TAKIEVPKNA AMPSTMSSVR IDEMVGNANG DPAAAADAKA PNPVTGQVQV 
421:	PGADTGVQTV TYDFPKGSPD EEADDASGIH FSAGNGKMRL DSSPSLVSVS GTLSRVNTVA 
481:	SALKRFLSRD DSRPGSATPS QDQPYKFPAS ASSASLSGAV VGSATSAGKP AGSLRITQQV 
541:	IEEVDEQATI TSMRANDPRP NVMDIFAQTS SGAGTSGPLQ PPPAHSEPVD IPSRPPSYNR 
601:	AQSQYEPNLF PPGGVDALLS TSAPAGGSPL LLSNAATAPS SPVGESSKSL YDPQKGASRE 
661:	TVESMDLRSS TDLLGDAAVQ PEDEGDDFDK LKAEREKEKL MRQQKNLART ISTAPGMEAT 
721:	AVPMVPMVPV NVAVQQAQLQ PVASSADLLA GGDQFSNSTM KSEDAINGS