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1.A.48.1.1
Tweety maxi-Cl- anion channel

Accession Number:Q9U6L4
Protein Name:Tweety of Drosophila melanogaster aka Tty (CG1693-PA)
Length:970
Molecular Weight:105828.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Cl-

Cross database links:

eggNOG: inNOG04647
RefSeq: NP_542443.4   
Entrez Gene ID: 33109   
Pfam: PF04906   
KEGG: dme:Dmel_CG1693   

Gene Ontology

GO:0034707 C:chloride channel complex
GO:0005886 C:plasma membrane
GO:0005254 F:chloride channel activity
GO:0006811 P:ion transport

References (5)

[1] “Data transferability from model organisms to human beings: insights from the functional genomics of the flightless region of Drosophila.”  Maleszka R.et.al.   9520435
[2] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[3] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[4] “A Drosophila complementary DNA resource.”  Rubin G.M.et.al.   10731138
[5] “The Drosophila melanogaster dodo (dod) gene, conserved in humans, is functionally interchangeable with the ESS1 cell division gene of Saccharomyces cerevisiae.”  Maleszka R.et.al.   8552658

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MGDYHEFTDQ YKVPVIAKLL HALPHYNITF HKINSTFRPN DEIYLESLGI LGSVPAALLI 
61:	VSLLGLLFYL MTRCCDRKPR PAHSITSLKV ALSIVTVMCC AAIGLGLYGN DDLHNGLLEV 
121:	LTAGRKVDNL VTTIRNQTHI LENTLTNRIR PQLVELADIF DQPVSNQTAL SKLFVSLNIV 
181:	QGNVTLATNA ASDIRRPLMG ISMTHFLTRG DQWELIRWPG TVATLALLLV LCAVLLVGVA 
241:	RHSRCALILF SVCGLLAVTG SWLMSGLYLS SSVAVGDLCI SPADFLVSTA PRDLPTNVLL 
301:	HYTQCEPGHT NPFTQRLRES QNSLNNARSA MATVMKISLV LFKSSGLQPK LGAVNADLNS 
361:	SERLLTQLTA LVDCKAVHHN FLAAARGLCE GGLLGLVLML IASFIAAILL TIMVWVDSHT 
421:	WIYIRKRNDY AQVDEPSYIS HPAPQNHQQM MNAARTLPRN HNGHFSPPVI SGSHTLQHPS 
481:	KRQQHEMMAH AHIQQNMRAM GTHTLGRLPS HNHSPTHMTG PNNAAAVAAA ANAAANMPPT 
541:	TQAAQQQQQQ QAQQQQQQAQ QQLGGPQPIY CHHPHQHPHP HPHQHPHSHS AAAVAAAVQH 
601:	QHAIYHQQQA QQYGTYTTAA HHAPHHLGPG QSQIYQQIPA HLAPQLAANG NPHSIYQPLV 
661:	AVSQGSIYVS NMATMRRQNS QGGPQIPAHQ HPPSLHQQQQ QPPPPSQQQQ QLHQLKSPQQ 
721:	HQQQLQQHQQ QQQQQHHQQQ HHQQQHQQQQ QQHHQQQQPN ESDVVPISTA MDTAIYDRDK 
781:	QIYKCSTLRQ GGKFDPKYKP SILNCPLPEI PKDAEQPKVE SIYEQRQQAH HQNYSKTLQR 
841:	PPMMLPPQMK AIPPPRIGTP TSPPPPVAQP LNESNGGVPS GLQNGGAVVG GGGANANEDT 
901:	SLPPPPLEAQ TEATKARMGA GPAANGKVLH NGGGGGSVGG GGGGAVDDDD DLPPPPPAIT 
961:	DESNYAVTEL