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1.A.48.1.2
TTYH1 maxi-Cl- anion channel

Accession Number:Q9H313
Protein Name:Protein tweety homolog 1
Length:450
Molecular Weight:49051.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Cl-

Cross database links:

Genevestigator: Q9H313
eggNOG: prNOG06278
RefSeq: NP_001005367.1    NP_065710.1   
Entrez Gene ID: 57348   
Pfam: PF04906   
OMIM: 605784  gene
KEGG: hsa:57348   

Gene Ontology

GO:0034707 C:chloride channel complex
GO:0005886 C:plasma membrane
GO:0005254 F:chloride channel activity
GO:0005381 F:iron ion transmembrane transporter activity
GO:0005515 F:protein binding
GO:0007155 P:cell adhesion
GO:0006826 P:iron ion transport

References (6)

[1] “Human and mouse homologues of the Drosophila melanogaster tweety (tty) gene: a novel gene family encoding predicted transmembrane proteins.”  Campbell H.D.et.al.   10950931
[2] “A novel human Cl(-) channel family related to Drosophila flightless locus.”  Suzuki M.et.al.   15010458
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The DNA sequence and biology of human chromosome 19.”  Grimwood J.et.al.   15057824
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Expression and evolution of the mammalian brain gene Ttyh1.”  Matthews C.A.et.al.   17116230

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGAPPGYRPS AWVHLLHQLP RADFQLRPVP SVFAPQEQEY QQALLLVAAL AGLGLGLSLI 
61:	FIAVYLIRFC CCRPPEPPGS KIPSPGGGCV TWSCIVALLA GCTGIGIGFY GNSETSDGVS 
121:	QLSSALLHAN HTLSTIDHLV LETVERLGEA VRTELTTLEE VLEPRTELVA AARGARRQAE 
181:	AAAQQLQGLA FWQGVPLSPL QVAENVSFVE EYRWLAYVLL LLLELLVCLF TLLGLAKQSK 
241:	WLVIVMTVMS LLVLVLSWGS MGLEAATAVG LSDFCSNPDP YVLNLTQEET GLSSDILSYY 
301:	LLCNRAVSNP FQQRLTLSQR ALANIHSQLL GLEREAVPQF PSAQKPLLSL EETLNVTEGN 
361:	FHQLVALLHC RSLHKDYGAA LRGLCEDALE GLLFLLLFSL LSAGALATAL CSLPRAWALF 
421:	PPSDDYDDTD DDDPFNPQES KRFVQWQSSI