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1.A.5.1.2
Polycystic kidney disease protein 1-like 3 (PC1-like 3 protein or PKD1L3) (Polycystin-1L3).  May particpate in formation of the TRP sour taste receptor (see 1.A.5.2.2) (Ishimaru et al. 2010). Mediates Ca2+ influx-operated Ca2+ entry that generates pronounced Ca2+ spikes. Triggered by rapid onset/offset of Ca2+, voltage, or acid stimuli, Ca2+-dependent activation amplifies a small Ca2+ influx via the channel which concurrently drives self-limiting negative feedback inactivation that is regulated by the Ca2+-binding EF hands of its partner protein, PKD2-L1 (Hu et al. 2015).

Accession Number:Q7Z443
Protein Name:Polycystic kidney disease protein 1-like 3
Length:1732
Molecular Weight:195894.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Genevestigator: Q7Z443
eggNOG: NOG12793
HEGENOM: HOG000230856
Pfam: PF01825    PF08016    PF01477   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0030246 F:carbohydrate binding
GO:0005216 F:ion channel activity
GO:0006812 P:cation transport
GO:0071468 P:cellular response to acidity
GO:0001581 P:detection of chemical stimulus involved in sensory perception of sour taste
GO:0007218 P:neuropeptide signaling pathway

References (1)

[1] “Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes.”  Li A.et.al.   12782129

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFFKGGSWLW LYIRTSIILG SELNSPAPHG QNNCYQLNRF QCSFEEAQHY CHVQRGFLAH 
61:	IWNKEVQDLI RDYLEEGKKW WIGQNVMPLK KHQDNKYPAD VAANGPPKPL SCTYLSRNFI 
121:	RISSKGDKCL LKYYFICQTG DFLDGDAHYE RNGNNSHLYQ RHKKTKRGVA IARDKMPPGP 
181:	GHLPTTCHYP LPAHLSKTLC HPISQFPSVL SSITSQVTSA ASEPSSQPLP VITQLTMPVS 
241:	VTHAGQSLAE TTSSPKEEGH PNTFTSYLQV SLQKASGQVI DEIAGNFSRA VHGLQALNKL 
301:	QEACEFLQKL TALTPRFSKP AQVNLINSLI YLSEELLRIP FQNNNSLGFK VPPTVCPFHS 
361:	LNNVTKAGEG SWLESKRHTE PVEDILEMSL VEFGNIGEAF LEQNQSPESS VTLTSANATL 
421:	LLSRQNISTL PLSSYTLGHP APVRLGFPSA LALKELLNKH PGVNVQITGL AFNPFKDLDN 
481:	RNIVGSIGSV LLSANRKLLQ VHDLMEDIEI MLWRNVSLET HPTSLNMSTH QLTITVNVTS 
541:	LEKSLIVSID PDSPLLMTLY LGFQYQPNCT HFHLNITLPK DKVWQKDEEY TWVLNPEHLQ 
601:	HGIGTYYITA VLSERQEGAQ QTPSLVSVIT AVTQCYYWEI HNQTWSSAGC QVGPQSTILR 
661:	TQCLCNHLTF FASDFFVVPR TVNVEDTIKL FLRVTNNPVG VSLLASLLGF YVITVVWARK 
721:	KDQADMQKVK VTVLADNDPS AQFHYLIQVY TGYRRSAATT AKVVITLYGS EGRSEPHHLC 
781:	DPQKTVFERG GLDVFLLTTW TSLGNLHSLR LWHDNSGVSP SWYVSQVIVC DMAVKRKWHF 
841:	LCNCWLAVDL GDCELDRVFI PVSKRELFSF RHLFSSMIVE KFTQDYLWLS IATRHPWNQF 
901:	TRVQRLSCCM TLLLCNMVIN VMFWKINSTT AKRDEQMRPF AVAWSELLVS IHTAVILFPI 
961:	NLVIGRLFPL IEPQETLPLF PPIQASCLSD ASVEPLSATM VVEELKETVR FLLRRNTYLL 
1021:	SKCEQPPWSS WDITKLVKLL SSLVSSHLEG QGCHQQGERH WARVVPENHH HFCCYLHRVL 
1081:	QRLKSHLGTL GLTQGHQSCD FLDAASQLQK LQELLETHIL PTEQEPSREV TSFAILSSEE 
1141:	GKKPISNGLS KWLTSVCWLL LGFTSLASAF FTALYSLELS KDQATSWMIS IILSVLQNIF 
1201:	ISQPVKVVFF TFLYSLMMSR MPRLNKENEQ QTKRILALLA KCSSSVPGSR DKNNPVYVAP 
1261:	AINSPTKHPE RTLKKKKLFK LTGDILVQIL FLTLLMTAIY SAKNSNRFYL HQAIWKTFSH 
1321:	QFSEIKLLQD FYPWANHILL PSLYGDYRGK NAVLEPSHCK CGVQLIFQIP RTKTYEKVDE 
1381:	GQLAFCDNGH TCGRPKSLFP GLHLRRFSYI CSPRPMVLIP TDELHERLTS KNENGFSYIM 
1441:	RGAFFTSLRL ESFTSLQMSK KGCVWSIISQ VIYYLLVCYY AFIQGCQLKQ QKWRFFTGKR 
1501:	NILDTSIILI SFILLGLDMK SISLHKKNMA RYRDDQDRFI SFYEAVKVNS AATHLVGFPV 
1561:	LLATVQLWNL LRHSPRLRVI SRTLSRAWDE VVGFLLIILI LLTGYAIAFN LLFGCSISDY 
1621:	RTFFSSAVTV VGLLMGISHQ EEVFALDPVL GTFLILTSVI LMVLVVINLF VSAILMAFGK 
1681:	ERKSLKKEAA LIDTLLQKLS NLLGISWPQK TSSEQAATTA VGSDTEVLDE LP