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1.A.5.2.4
Polycystin-2 (CePc2) (Polycystic kidney disease 2 protein homologue)

Accession Number:Q9U1S7
Protein Name:Polycystin-2
Length:716
Molecular Weight:80435.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

eggNOG: NOG325704
HEGENOM: HOG000230858
Entrez Gene ID: 178424   
Pfam: PF08016   
KEGG: cel:Y73F8A.1   

Gene Ontology

GO:0030424 C:axon
GO:0060170 C:cilium membrane
GO:0030425 C:dendrite
GO:0005783 C:endoplasmic reticulum
GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane
GO:0043025 C:neuronal cell body
GO:0031513 C:nonmotile primary cilium
GO:0031090 C:organelle membrane
GO:0043204 C:perikaryon
GO:0005262 F:calcium channel activity
GO:0005509 F:calcium ion binding
GO:0034606 P:response to hermaphrodite contact
GO:0034608 P:vulval location

References (11)

[1] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[2] “A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans.”  Barr M.M.et.al.   10517638
[3] “The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway.”  Barr M.M.et.al.   11553327
[4] “Towards understanding the polycystins.”  Kaletta T.et.al.   12411744
[5] “Polycystin-2 accelerates Ca2+ release from intracellular stores in Caenorhabditis elegans.”  Koulen P.et.al.   15862350
[6] “The KLP-6 kinesin is required for male mating behaviors and polycystin localization in Caenorhabditis elegans.”  Peden E.M.et.al.   15753033
[7] “ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling.”  Hu J.et.al.   15563610
[8] “General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia.”  Bae Y.-K.et.al.   16943275
[9] “Casein kinase II and calcineurin modulate TRPP function and ciliary localization.”  Hu J.et.al.   16481400
[10] “STAM and Hrs down-regulate ciliary TRP receptors.”  Hu J.et.al.   17581863
[11] “Distinct protein domains regulate ciliary targeting and function of C. elegans PKD-2.”  Knobel K.M.et.al.   18037411

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MNYGAADERW ANPPQPVAAA EHGPSFDHSM VSEEYEHDKK KNPAQKEGIS FSQALLASGH 
61:	EKSDGKIKLT ARSFMEVGGY AVFLIVLVYV AFAQNSIQSY YYSKVMSDLF VASTGASGAP 
121:	AFGSCTSMDN IWDWLSQVLI PGIYWTETSN STDNENMIYY ENRLLGEPRI RMLKVTNDSC 
181:	TVMKSFQREI KECFANYEEK LEDKTMVGDG SVDAFIYATA KELENLKTVG TIASYGGGGF 
241:	VQRLPVAGST EAQSAIATLK ANRWIDRGSR AIIVDFALYN ANINLFCVVK LLFELPASGG 
301:	VITTPKLMTY DLLTYQTSGG TRMMIFEGIF CGFILYFIFE ELFAIGRHRL HYLTQFWNLV 
361:	DVVLLGFSVA TIILSVNRTK TGVNRVNSVI ENGLTNAPFD DVTSSENSYL NIKACVVFVA 
421:	WVKVFKFISV NKTMSQLSST LTRSAKDIGG FAVMFAVFFF AFAQFGYLCF GTQIADYSNL 
481:	YNSAFALLRL ILGDFNFSAL ESCNRFFGPA FFIAYVFFVS FILLNMFLAI INDSYVEVKA 
541:	ELARKKDGEG ILDWFMNKVR GLTKRGKRPD APGEDATYED YKLMLYRAGY AEKDINEAFT 
601:	RFNVTSMTEH VPEKVAEDIA DEVARMTEQK RNYMENHRDY ANLNRRVDQM QESVFSIVDR 
661:	IEGVNATLQT IEKQRVQQQD GGNLMDLSAL LTNQVRNRES AARRPTITSI ADKKEE