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1.A.5.3.2
The TRP-ML3 or TRPML3 or Mcoln3 (Mucolipin-3) inward rectifying cation channel; associated with the mouse Viartini-Waddler phenotype when mutant (A419P) (Kim et al., 2007; Cuajungco and Samie 2008). H+-regulated Ca2+ channel that shuttles between intracellular vesicular compartments and the plasma membrane (Kim et al., 2010).

Accession Number:Q8R4F0
Protein Name:Trp-ML3
Length:553
Molecular Weight:63748.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

Genevestigator: Q8R4F0
HEGENOM: HBG444433
RefSeq: NP_598921.1   
Entrez Gene ID: 171166   
Pfam: PF08016   
KEGG: mmu:171166   

Gene Ontology

GO:0005737 C:cytoplasm
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005216 F:ion channel activity
GO:0042491 P:auditory receptor cell differentiation
GO:0006811 P:ion transport
GO:0007626 P:locomotory behavior

References (2)

[1] “Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice.”  Di Palma F.et.al.   12403827
[2] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MANPEVLVSS CRARQDESPC TFHPSSSPSE QLLLEDQMRR KLKFFFMNPC EKFWARGRKP 
61:	WKLAIQILKI AMVTIQLVLF GLSNQMVVAF KEENTIAFKH LFLKGYMDRM DDTYAVYTQS 
121:	EVYDQIIFAV TQYLQLQNIS VGNHAYENKG TKQSAMAICQ HFYRQGTICP GNDTFDIDPE 
181:	VETECFLVEP DEASHLGTPG ENKLNLSLDF HRLLTVELQF KLKAINLQTV RHQELPDCYD 
241:	FTLTITFDNK AHSGRIKISL DNDISIKECK DWHVSGSIQK NTHYMMIFDA FVILTCLASL 
301:	VLCARSVIRG LQLQQEFVNF FLLHYKKEVS ASDQMEFING WYIMIIISDI LTIVGSVLKM 
361:	EIQAKSLTSY DVCSILLGTS TMLVWLGVIR YLGFFAKYNL LILTLQAALP NVMRFCCCAA 
421:	MIYLGYCFCG WIVLGPYHEK FRSLNRVSEC LFSLINGDDM FSTFAKMQQK SYLVWLFSRV 
481:	YLYSFISLFI YMILSLFIAL ITDTYETIKH YQQDGFPETE LRKFIAECKD LPNSGKYRLE 
541:	DDPPGSLLCC CKK