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1.A.5.4.1
The algal PDK2 cation channel in Chlamydomonas reinhardii, involved in coupling flagellar adhesion at the beginning of mating to the increase in flagellar calcium required for subsequent steps in mating (Huang et al., 2007). (Residues 1278-1346 (the PKD domain) are 25% identical, 54% similar to residues 107-176 in CcaA (TC# 1.A.1.14.2))

Accession Number:A9LE42
Protein Name:PDK2
Length:1626
Molecular Weight:181133.00
Species:Chlamydomonas reinhardtii [3055]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Mitochondrion membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

Pfam: PF08016   

References (1)

[1] “Function and dynamics of PKD2 in Chlamydomonas reinhardtii flagella.”  Huang K.et.al.   17984324

External Searches:

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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAPLQAEDPQ KYRLEEGDGT THAQRIVREL YQRYERQLQR WKDYRNLFIF LCFVALFLGV 
61:	LYEQRNAGIS YQVHSTIESV AAPSDNIMQD TDAVYSWLNG LLTEVWKDPV CGDGLCEAPF 
121:	EFASYSRFGC RADCGKLSEV QNLTKIQIDI YYDFSHPVGS IPASDLMQQA SWNLCPLATA 
181:	YSSDCYFDAD KEFDRLSGVQ NFVLDDAPDG DWNLVVRRDI FNKIRGAVRD TTLVYASAFY 
241:	YKIYVAAAAA RAEQAFEISL LNQAINITSQ DFWTYANSVI MAGYPNATEY DAAVGWVKNA 
301:	TCFCDSVAND TVASGTPFTP EALMLYLNQS VSATDPNAPF SYTLTQYKND PYYCASGPFD 
361:	PREWRGRNVT VNSTAVNATA NSTASSGNVT WTKELVTINM ANQTALRDWC VGGLNLSIAW 
421:	RTNMTNTVQR LLIDRRLGDQ RTTGKIAQRN NVNDRMLAFI RANRPELVAP VFNAPRGTVA 
481:	LQDPINARLE YLYPLYVDGV KYSTEPQRAA LNMTRRIVYN TTVHLLSLRP RAAARIAEVQ 
541:	EQIADVRAIA LPTPITSYQN YTFPNATVGD VYDAFINAGA TSFTVPAPTN SSLGAFQVSY 
601:	NLVEWLGNTT AYMRCDLADR GAEYEGECVA MNNTCIATTN DTVPYNCTDL TNNGATITGN 
661:	LSNPDYRMRC ETPCDRRFDC NTICECYGTC AATEYCECDA CIQLNVNAAA DTQFVDIRSI 
721:	VQDQAAASAS IASIGLSGTV NRRASRRLLT TNEEIAAQLS NVLTQVGTVS TQQGSIATQM 
781:	ATLKAQVDRA NQLAEARAND NRLIDLINAG RADIQAGQAR VEAKLDEIIG KQNQALAAAE 
841:	DAAKALSAIQ GLAERQVAAQ RALETAVTNQ LSAIKTATYQ SIITLTQALA LWKRARRDKA 
901:	LTLKAAKLAN VPCTSDPVST NTFTLDNGNI VDTTTSRERN VGLTNRVIGG LLLHQTRTNE 
961:	TLCPESKFDK IQKTCTGPQT VASFGVDPIF KRGTTLYNPD YDDVNGTKVL DFYNCSVLSS 
1021:	PTYNVSFLNQ TVNPAPYCAE LYNPQELPYA FHFFPLSGKD DGFPVWFDIN LSQDGAQTWF 
1081:	TYLQEGLYLD QNTRTMTAEM VTYNAPLRIF SYFYIKFYFS DGGSIKVTYR LNTARVELQN 
1141:	SYEDDVRFGF EIILSIWISL LLLINFWDIG NCQKTKGNFL KYFLSGWNWV EFCSNGLLFS 
1201:	CMVMWWVISS KYASKFEIPI RRDVYAGLSA EANFLALQSN GAWLNEANND FEELKQLVDM 
1261:	FNWYFALNGI NILLLIARVL KLMDFQPRLG VVTRSLWLAG PDLCHFAIVA GMVFVGYAMM 
1321:	GHLIFGNAIP AFATFGDAIN TCFEILLGNI DVNSDLRALG GLQSVAGALW FWSYELLVYM 
1381:	VLLNFLLAII VDAFSEVKEK THETVGIHTE LFQLMRDKWR SLLGSFSPNY ISDAKLGDLL 
1441:	RQWAGEGDDK DDSPEVREEK RKLLTILNED MDEETLREVF EECLRDAPAA DPKAKQGNVL 
1501:	ARLFKRNVGA GDTDATKKEI EQAAHYIVER FGAVPDDYDE DEDDDQEQLQ AAPQQAIMGG 
1561:	GGMPAAPGAR EAVLEKERDQ LAQALERLAE VQRELAEGQR NLMSGQKQLA EQQSKLVQLM 
1621:	NETPPQ