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1.A.50.1.1
Phospholamban (PLB) pentameric Ca2+/K+ channel (Kovacs et al., 1988; Smeazzetto et al. 2013; Smeazzetto et al. 2014).  In spite of extensive experimental evidence, suggesting a pore size of 2.2 Å, the conclusion of ion channel activity for phospholamban has been questioned (Maffeo and Aksimentiev 2009).

Accession Number:P26678
Protein Name:PPLA aka PLB aka PLN
Length:52
Molecular Weight:6109.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Mitochondrion membrane1 / Single-pass membrane protein2

Cross database links:

Genevestigator: P26678
eggNOG: maNOG21649
HEGENOM: HBG125007
RefSeq: NP_002658.1   
Entrez Gene ID: 5350   
Pfam: PF04272   
OMIM: 172405  gene
609909  phenotype
KEGG: hsa:5350   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0031966 C:mitochondrial membrane
GO:0016529 C:sarcoplasmic reticulum
GO:0042030 F:ATPase inhibitor activity
GO:0005246 F:calcium channel regulator activity
GO:0005515 F:protein binding
GO:0008015 P:blood circulation
GO:0006816 P:calcium ion transport
GO:0051924 P:regulation of calcium ion transport

References (9)

[1] “Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to human chromosome 6.”  Fujii J.et.al.   1828805
[2] “The human phospholamban gene: structure and expression.”  McTiernan C.F.et.al.   10198197
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Phospholamban interacts with HAX-1, a mitochondrial protein with anti-apoptotic function.”  Vafiadaki E.et.al.   17241641
[5] “Solution structure of the cytoplasmic domain of phospholamban: phosphorylation leads to a local perturbation in secondary structure.”  Mortishire-Smith R.J.et.al.   7779806
[6] “Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban.”  Adams P.D.et.al.   7749920
[7] “Using experimental information to produce a model of the transmembrane domain of the ion channel phospholamban.”  Herzyk P.et.al.   9512019
[8] “Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban.”  Schmitt J.P.et.al.   12610310
[9] “A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.”  Haghighi K.et.al.   16432188
Structure:
1K9N   1KCH   1PLN   1PLP   1PSL   1ZLL   2HYN     

External Searches:

  • Search: DB with
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  • CDD Search (Conserved Domain Database)
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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEKVQYLTRS AIRRASTIEM PQQARQKLQN LFINFCLILI CLLLICIIVM LL