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1.A.51.1.3
Voltage-gated proton channel, HvCN1; VSOP; VSX1 (Sasaki et al., 2006).  Exhibits voltage and pH-dependent gating as well as Zn2+-reactivity. In the dimeric strcuture, each subumit has a proton channel. TMS4 appears to be the voltage sensor.  Subunit cooperativity has been demonstrated (Gonzalez et al. 2010).    

Accession Number:Q1JV40
Protein Name:Voltage-gated hydrogen channel 1
Length:342
Molecular Weight:38501.00
Species:Ciona intestinalis (Transparent sea squirt) [7719]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate H+

Cross database links:

eggNOG: meNOG14320
DIP: DIP-46135N
Entrez Gene ID: 778897   
Pfam: PF00520   
KEGG: cin:778897   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005244 F:voltage-gated ion channel activity

References (1)

[1] “A voltage sensor-domain protein is a voltage-gated proton channel.”  Sasaki M.et.al.   16556803

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEGDNCNKSR HKSHNMINPN YASVRCTQPL PSVIQLRSRN KMIGITEDPS SDSEPVSSNQ 
61:	PLLLTNLSYE VHTFNDNNNH ERPAPQEQST QNTMISMQSE QKSDRFTASN LGMFQYMKFE 
121:	IGEDGDDHEE EAILTNREKL RHILHSKPIH VAIIVLVVLD SFLVVGELLI DLKVIIVPHG 
181:	NPAPEILHGF SLSILSIFMV EIALKIIADH RHFIHHKVEV LDAVVVVISF GVDIALIFVG 
241:	ESEALAAIGL LVILRLWRVF RIINGIIVTV KTKADDRVHE IKKKNSELEL QIHNLEEKLS 
301:	QKEQDMSRLH EILRCNNIDI PPTVPLTTSV QIHSTTTASA DV