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1.A.52.1.2
The ARC (Arachidonate-regulated Ca2+-selective) channel, a complex of STIM1, Orai1 and Orai3 (Mignen et al., 2008). It is a heteropentameric assembly of three Orai1 subunits and two Orai3 subunits (Mignen et al., 2009). (But see Demuro et al., 2011; 1.A.52.1.1). Molecular determinants within the N-terminus control channel activation and gating (Bergsmann et al., 2011).  Specifically activated by high concentrations (>50 microM) of 2-aminoethyl diphenylborinate (2-APB) (Amcheslavsky et al. 2014).

Accession Number:Q9BRQ5
Protein Name:Orai3
Length:295
Molecular Weight:31499.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Genevestigator: Q9BRQ5
eggNOG: prNOG15517
HEGENOM: HBG715505
RefSeq: NP_689501.1   
Entrez Gene ID: 93129   
Pfam: PF07856   
OMIM: 610930  gene
KEGG: hsa:93129   

Gene Ontology

GO:0016021 C:integral to membrane

References (2)

[1] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[2] “A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.”  Feske S.et.al.   16582901

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKGGEGDAGE QAPLNPEGES PAGSATYREF VHRGYLDLMG ASQHSLRALS WRRLYLSRAK 
61:	LKASSRTSAL LSGFAMVAMV EVQLESDHEY PPGLLVAFSA CTTVLVAVHL FALMVSTCLL 
121:	PHIEAVSNIH NLNSVHQSPH QRLHRYVELA WGFSTALGTF LFLAEVVLVG WVKFVPIGAP 
181:	LDTPTPMVPT SRVPGTLAPV ATSLSPASNL PRSSASAAPS QAEPACPPRQ ACGGGGAHGP 
241:	GWQAAMASTA IMVPVGLVFV AFALHFYRSL VAHKTDRYKQ ELEELNRLQG ELQAV