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1.A.52.1.5
Ca2+ release-activated Ca2+ (CRAC) channel subunit, Orai, which mediates Ca2+ influx following depletion of intracellular Ca2+ stores.  In Greek mythology, the 'Orai' are the keepers of the gates of heaven.  The crystal structure (3.35 Å), revealed a hexameric assembly of Orai subunits arranged around a central ion pore which traverses the membrane and extends into the cytosol. A ring of glutamate residues on its extracellular side forms the selectivity filter. A basic region near the intracellular side can bind anions that may stabilize the closed state. The architecture of the channel differs from those of other solved ion channels (Hou et al. 2012).

Accession Number:Q9U6B8
Protein Name:Calcium release-activated calcium channel protein 1
Length:351
Molecular Weight:38507.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Structure:
4HKR   4HKS     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSVWTTANNS GLETPTKSPI TSSVPRAARS SAVITTGNHQ QHHFQHVVAA AVAAATSVAT 
61:	GHQFQQQFPL HAHPHPQHHS NSPTGSGSNS NNSAGFQRTS ISNSLLQFPP PPPPSSQNQA 
121:	KPRGHHRTAS SSMSQSGEDL HSPTYLSWRK LQLSRAKLKA SSKTSALLSG FAMVAMVEVQ 
181:	LDHDTNVPPG MLIAFAICTT LLVAVHMLAL MISTCILPNI ETVCNLHSIS LVHESPHERL 
241:	HWYIETAWAF STLLGLILFL LEIAILCWVK FYDLSPPAAW SACVVLIPVM IIFMAFAIHF 
301:	YRSLVSHKYE VTVSGIRELE MLKEQMEQDH LEHHNNIRNN GMNYGASGDI V