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1.A.53.1.1
HCV-P7 (Clarke et al., 2006).  It's mechanism and  function have been investigated in considerable detail (Gan et al. 2014).  Histidine-17, which faces the lumen of the pore when protonated, allows Cl- entry, but deprotonation also allows Ca2+ entry.  Imposition of voltage creates a Cl- current (Wang et al. 2014). The structure and dual pore/ion channel activity of p7 of different HCV genotypes have been reviewed (Madan and Bartenschlager 2015). It may transport protons; it's structure has been determined by NMR (Montserret et al. 2010) and by electron microscopy (Luik et al. 2009).  The p7 N-terminal helical region is critical for E2/p7 processing, protein-protein interactions, ion channel activity, and infectious HCV production (Scull et al. 2015).

Accession Number:Q5QRI8
Protein Name:P7 aka Polyprotein
Length:63
Molecular Weight:6778.00
Species:Hepatitis C virus subtype 1b [31647]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Secreted1
Substrate Cl-, Ca2+

Cross database links:

References (1)

[1] “Hepatitis C Virus p7 membrane protein quasispecies variability in chronically infected patients treated with interferon and ribavirin, with or without amantadine.”  Castelain S.et.al.   17177298

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	ALENLVVLNA ASLAGAHGIL SFLVFFCAAW YIKGRLVPGA AYAFYGVWPL LLLLLTLPPR 
61:	AYA