TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.53.1.3
Polyprotein containing p7 of hepacivirus AK.  Ion channel activity has been demonstrated in lipid bilayers (Walter et al. 2016).

Accession Number:I1ZAT0
Protein Name:Genome polyprotein
Length:2937
Molecular Weight:322802.00
Species:Hepacivirus AK-2012 [1173523]
Number of TMSs:13
Substrate ions

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MGNKSKNQKP KPQRGPRNRV KGQSRSGPVV FPSGAVLVGG RYIPPPKKAI RGPRRGLVQA 
61:	PKSSERTAPR HRRQPPPQTD SSWRKYFPKF WGDKGYPWPY VDSVLQWGAW GSSPGAYRTR 
121:	WGPRDPRHRS RNLGRVIDTL TCGVADLAGY VPVLGAPAGA LCRGAAHLVR FVEDGANFIT 
181:	GNIPGMGFSI FLLALFSAVS FGEASVVRNG GHVVSNDCNQ SQILWAASDW AIHEVGCVPC 
241:	VDSACWVPLT SSISVRNESV IVRGLGSHID VVAAMASVCS TLGIGEACGT ATLTYITFLS 
301:	RFFIRLNLTY DCECFLYPGA ISTFEFTMRA LQSMMPNLSG FVSMFSGLPN TLFTIFTNGH 
361:	WGVILALCLY GTTNNYFKLC LLLLAYSGLV SCSEDYINVS LSCNFTIKQM WGWTFFPKWA 
421:	LLNGQRLNCT PGSPYNPKCK GPMDFNITTD PVVTYSGTRS HPPCPYHVSR PCSVLNASRV 
481:	CGKPTCFGPA PIEVGVTDRD GNLASWNDTG QFFFDLRSPH RPPRGRWYGC VWLNSTGWVK 
541:	QCGAPPCVMN LVSNKSRTFI CPSDCFRQNP KATYQLCGQG PWITHNCLID YTDRYLHFPC 
601:	TENFTVYPVR MILGDGARDV RVACNFNRSV SCRTEDRLRA SIVSLLYSVT TAAVPPCHFS 
661:	PLPAFTTGLI HLDRNLSDVQ YVWAMTPSAV NVFLRLEWAV FFLLLLMDAK VCAILWFCLC 
721:	LALQAEAYLS DTMRLIALSY IADDSLLWAL VFYCVIYFTP SRLPPFCVFV YYWKFALAFM 
781:	VLALPHRAWA FDNASAVTAA FSMALFCLYV TCLSCYKRLF MLVKWWLEYW DVRVECAWRY 
841:	LGPRVNPRDE KLAFALIFAF LHPPLFRCIY LPLAVVCGSF SMINKRVQKI SYLRRAEVLV 
901:	KVLAFCRDLY GSKWVQWCVL WVASYFGTFL YNHLTPIDTW AAPGLRDLMH SLEPITLSPM 
961:	ERKVVKWGAR KVACGDILHG LPVSARLGRE ICLGPADKLS SKGWRLLSPI TATVTKTRGI 
1021:	PSAIVCCLTG RDKYPHRGHC YILTSLTKTF MGTVCKGVLW SVHHGGGTAT LASDKSSLLQ 
1081:	VLCSPGDDLV AWPAPAGSKS FQPCTCGSAD VFLVTRTGQV VPARKTSEKD ASLISPLPIS 
1141:	SLKGSSGGPV LCKDGDLVGI FCSASVTRGV AKRIHFADMR TRSVSSCPPK YTDLDTPPAV 
1201:	PSSYQVSFLH APTGSGKSTK MPLSYVELGY HVLVLNPSVA STLSFGPYMD KTYGECPNIR 
1261:	TGASCKTTGS KLTYSTYGKF LADGGVSAGA YDIIICDECH STDSTSVLGI GSVLDGAESK 
1321:	GVKLVVLATA TPPGSQTVPH PNIDEEALTQ SGDIPFYGKM LKSSMLLSGR HLIFCHSKKK 
1381:	CEEVALLLRK AGANAVTYYR GLDVSVIPNE GNVVVVATDA LMTGYSGNFD TVTDCNTAVE 
1441:	LDIEFSLDPT FTMVTTPKPS DAVCRTQRRG RTGRGRRGTY YYVNSGERPS GVLSSSVLCE 
1501:	CYDSGLAWFG LSPAQVTVLL QAYLKQPGLP TGLDHTEFWE SVFIGLPTVD AFFLSQLKQQ 
1561:	GVTFPYLTAI QATVCLNAQA KAPSKDERWK VLSRYITTNR TPTPLLYRLE DTHDDLTFTH 
1621:	PVTKYIQACM EAEIDTQTNA WVIAGGCIAA LVAVAALTGS VAIIAEVHVN EKVVVVPHKG 
1681:	VLYADFDELE ECFDHHQYIQ QGYEWASRAA QKIREVASSI DPPTGQAQPM LSAIEKFWNQ 
1741:	HMWNILSGVQ YLAGLTTLPY NPSVACLMGF VSGLTTGLPR PAMAFLTILG GWAASMVAPP 
1801:	QAASTFVGAG LAGIAIGAVG FTDVIVGLLA GYGAGVAGAL TAFKILSGVT PSGEDLINLL 
1861:	PSLLNPGALA VGVGAAFILK RYTGGSEGLV AWVNRLIAFC SRGNHVSPDH YVQQQQVVRD 
1921:	VIACLESLTL TRLVKTIHNF VTSENDQNCD FTAIYFFIQW LMKALYDCFT WAKGIILPHL 
1981:	PGLPIISCDY GYSGRWAGDG IITTRCGCGN LITGNVRNEK IRITGSRRCR NLWLNTFPIN 
2041:	STTTGGPRPN PYDTWKTAVL RITSTEYVEF KRERNAVRVI GATADKLRIP CQVPEPDLMT 
2101:	FIDGVRIHRL APSPKPMLRD EVVVLIGNHT YPVGATLPCT PEPDVDTVSS LLTDPGHVTA 
2161:	ETAARRLRRG RTVDVESSSG SELSAVSRGA ASRVSEEHEM AGGPVRPLTG EDELAWIRSF 
2221:	YGRSVTIEVD DKVINFDSWT INSGSEGEHS RESVGAPDDD RVVVAEPPPP PGPAWMRKDY 
2281:	VPALVSGCPI KPGSATPEPS EPSATESAPV EETEEPKEDE KGEETDPDMP PLEGEEPEED 
2341:	DSSQWETTSD KAESCSLSYS WTGALVTATR REERRHPIGP LSNTLITRHN LVYQTTTASA 
2401:	SARMAKVTID REQVLDKYYF DTVTQIKNRA REVTAHLLSW DEVARLTPKN TARAKSGLSG 
2461:	SDVRKLTRAA RRELNSTWQD LLSSSDEPIP TTVMAKNEVF VSSPTARKPA RLIVYPDLSV 
2521:	RACEKRAMYD LFQKLPYAIM GKAYGFQYTP RQRVSRLLDM WRTFKNPMGF SYDTKCFDST 
2581:	VTPHDIDTER DIFLSANLPD EAQTVIKNLT SRLYRGSPMY NSRGDLVGKR ECRASGVFPT 
2641:	SMGNTLTNYI KATAAAKAAG FADPQFLICG DDLVCVTSSK GVEEDEQALR EFTNAMTKYS 
2701:	AIPGDLPKPY YDLEQITSCS SNVTVAQDRN GRPYYFLTRD PTTPLARASW ETISHSPVNS 
2761:	WLGNIIAFAP TLWVRLVFLT HFFGLLLQQD AVDQNYEFEM YGSTYSVNPL DLPAIIYKLH 
2821:	GPEAFDLTNY SPYEVQRVAA ALQKLGSPPL RAWKRRAKLV RSKLKVRGGR YSVVADYLFG 
2881:	FASAYRPKRP APPGVNSIDV SGWFSIGDDS LGDIYRQLPI VAGRWIPLLL LLPLLAA