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1.A.53.1.4
CSFVA viroporin (70 aas; 2 TMSs). CSFV viroporin p7 protein induces IL-1β secretion which is inhibited by the ion channel blocker amantadine. The p7 protein is a short-lived protein degraded by the proteasome (Lin et al. 2014). CSFV-p7 forms pores wide enough to allow ANTS (MW, 427 Da) release. Two pore structures with slightly different sizes and opposite ion selectivities were detected (Largo et al. 2016). The relative abundances of these pore types depend on membrane composition suggesting that the physicochemical properties of the lipid bilayers present in the cell endomembrane system modulate viroporin activity.

Accession Number:Q9YS30
Protein Name:Polyprotein
Length:3898
Molecular Weight:437638.00
Species:Classical swine fever virus [11096]
Number of TMSs:8
Substrate ions

Cross database links:

Pfam: PF11889    PF07652    PF00271    PF05550    PF12387    PF05578    PF00998   

Gene Ontology

GO:0033644 C:host cell membrane
GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0008026 F:ATP-dependent helicase activity
GO:0004197 F:cysteine-type endopeptidase activity
GO:0033897 F:ribonuclease T2 activity
GO:0003723 F:RNA binding
GO:0003968 F:RNA-directed RNA polymerase activity
GO:0004252 F:serine-type endopeptidase activity
GO:0070008 F:serine-type exopeptidase activity
GO:0044419 P:interspecies interaction between organisms
GO:0006508 P:proteolysis
GO:0006351 P:transcription, DNA-dependent
GO:0019079 P:viral genome replication
GO:0019082 P:viral protein processing

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MELNHFELLY RTNKQKPMGV EEPVYDATGR PLFGDPSEVH PQSTLKLPHD RGRGNIKTTL 
61:	NNLPRKGDCR SGNHLGPVSG IYVKPGPVFY QDYMGPVYHR APLEFFNETQ FCEVTKRIGR 
121:	VTGSDGKLYH IYVCIDGCIL LKLAKRGEPR TLKWIRNFTD CPLWVTSCSD DGASGSKEKK 
181:	PDRINKGKLK IAPKEHEKDS RTKPPDATIV VEGVKYQVKK KGKVKGKNTQ DGLYHNKNKP 
241:	PESRKKLEKA LLAWAVITIM LYQPVEAENI TQWNLSDNGT NGIQHAMYLR GVSRSLHGIW 
301:	PEKICKGVPT YLATDTELKE IQGMMDASEG TNYTCCKLQR HEWNKHGWCN WYNIDPWIQL 
361:	MNRTQANLAE GPPAKECAVT CRYDKDADIN VVTQARNRPT TLTGCKKGKN FSFVGTIIEG 
421:	PCNFNVSVED ILYGDHECGS LLQDTALYLV DGMTNTIENA RQGAARVTSW LGRQLSTAGK 
481:	RLEGRSKTWF GAYALSPYCN VTSKIGYIWY TNNCTPACLP KNTKIIGPGK FDTNAEDGKI 
541:	LHEMGGHLSE FLLLSLVVLS DFAPETASAL YLILHYVIPQ SYEEPEGCDT NQLNLTVELR 
601:	TEDVIPSSVW NVGKYVCVRP DWWPYETKVA LLFEEAGQVV KLALRALRDL TRVWNSASTT 
661:	AFLICLIKVL RGQIVQGVIW LLLVTGAQGR LACKEDYRYA ISSTNEIGLL GAGGLTTTWK 
721:	EYSHDLQLND GTVKAICVAG SFKVTALNVV SRRYLASLHK GALLTSVTFE LLFDGTNPST 
781:	EEMGDDFGFG LCPFDTSPVV KGKYNTTLLN GSAFYLVCPI GWTGVIECTA VSPTTLRTEV 
841:	VKTFRREKPF PHRMDCVTTT VENEDLFYCK LGGNWTCVKG EPVVYTGGQV KQCKWCGFDF 
901:	NEPDGLPHYP IGKCILANET GYRIVDSTDC NRDGVVISAE GSHECLVGNT TVKVHASDER 
961:	LGPMPCRPKE IVSSAGPVRK TSCTFNYAKT LKNKYYEPRD SYFQQYMLKG EYQYWFDLDV 
1021:	TDRHSDYFAE FVVLVVVALL GGRYVLWLIV TYIVLTEQLA AGLPLGQGEV VLIGNLITHT 
1081:	DIEVVVYFLL LYLVMRDEPI KKWILLLFHA MTNNPVKTIT VALLMVSGVA KGGKIDGGWQ 
1141:	RLPETSFDIQ LALTVIVVAV MLLAKRDPTT VPLVITVATL RTAKMTNGLS TDIAIATVST 
1201:	ALLTWTYISD YYRYKTWLQY LISTVTGIFL IRVLKGIGEL DLHTPTLPCY RPLFFILVYL 
1261:	ISTAVVTRWN LDIAGLLLQC VPTLLMVFTM WADILTLILI LPTYELTKLY YLKEVKIGAE 
1321:	RGWLWKTNFK RVNDIYEVDQ AGEGVYLFPS KQKTSSITGT MLPLIKAILI SCISNKWQFI 
1381:	YLLYLIFEVS YYLHKKIIDE IAGGTNFISR LVAALIEANW AFDNEEVRGL KKFFLLSSRV 
1441:	KELIIKHKVR NEVMVHWFGD EEVYGMPKLV GLVKAATLSK NKHCILCTVC EDREWKGETC 
1501:	PKCGRFGPPM TCGMTLADFE EKHYKRIFFR EDQSEGPVRE EYAGYLQYRA RGQLFLRNLP 
1561:	VLATKVKMLL VGNLGTEVGD LEHLGWVLRG PAVCKKVTEH EKCTTSIMDK LTAFFGVMPR 
1621:	GTTPRAPVRF PTSLLKIRRG LETGWAYTHQ GGISSVDHVT CGKDLLVCDT MGRTRVVCQS 
1681:	NNKMTDESEY GVKTDSGCPE GARCYVFNPE AVNISGTKGA MVHLQKTGGE FTCVTASGTP 
1741:	AFFDLKNLKG WSGLPIFEAS SGRVVGRVKV GKNEDSKPTK LMSGIQTVSK STTDLTEMVK 
1801:	KITTMNRGEF RQITLATGAG KTTELPRSVI EEIGRHKRVL VLIPLRAAAE SVYQYMRQKH 
1861:	PSIAFNLRIG EMKEGDMATG ITYASYGYFC QMPQPKLRAA MVEYSFIFLD EYHCATPEQL 
1921:	AIMGKIHRFS ENLRVVAMTA TPAGTVTTTG QKHPIEEFIA PEVMKGEDLG SEYLDIAGLK 
1981:	IPVEEMKSNM LVFVPTRNMA VETAKKLKAK GYNSGYYYSG EDPSNLRVVT SQSPYVVVAT 
2041:	NATESGVTLP DLDVVVDTGL KCEKRIRLSS KMPFIVTGLK RMAVTIGEQA QRRGRVGRVK 
2101:	PGRYYRSQET PVGSKDYHYD LLQAQRYGIE DGINITKSFR EMNYDWSLYE EDSLMITQLE 
2161:	ILNNLLISEE LPMAVKNIMA RTDHPEPIQL AYNSYETQVP VLFPKIRNGE VTDSYDNYTF 
2221:	LNARKLGDDV PPYVYATEDE DLAVELLGSD WPDPGNQGTV EAGRALKQVV GLSTAENALL 
2281:	VALFGYVGYQ ALSKRHIPVV TDIYSIEDHR LEDTTHLQYA PNAIKTEGKE TELKELAQGD 
2341:	VQRCVEAMTN YAREGIQFMK SQALKVKETP TYKETMDTVT DYVKKFMEAL KDSKEDIMKY 
2401:	GLWGTHTALY KSISARLGSE TAFATLVVKW LAFGGESIAD HVKQAATDLV VYYIINRPQF 
2461:	PGDTETQQEG RKFVASLLVS ALATYTYKSW NYNNLSKIVE PALATLPYAA TALKLFAPTR 
2521:	LESVVILSTA IYKTYLSIRR GKSDGLLGTG VSAAMEIMSQ NPVSVGIAVM LGVGAVAAHN 
2581:	AIEASEQKRT LLMKVFVKNF LDQAATDELV KESPEKIIMA LFEAVQTVGN PLRLVYHLYG 
2641:	VFYKGWEAKE LAQRTAGRNL FTLIMFEAVE LLGVDSEGKI RQLSSNYILE LLYKFRDSIK 
2701:	SSVREMAISW APAPFSCDWT PTDNRIGLPQ DNFLQVETKC PCGYKMKAVK NCAGELRLLE 
2761:	EEGSFLCRNK FGRGSRNYKV TKYYDDNLSE IKPVIKMEGH VELYYKGATI KLDFNNSKTI 
2821:	LATDKWEVDH STLVRVLKRH TGAGYNGAYL GEKPNHKHLI ERDCATITKD KVCFLKMKRG 
2881:	CAFTYDLSLH NLTRLIELVH KNNLEDKEIP AVTVTTWLAY TFVNEDIGTI RPAFGEKVTP 
2941:	EMQEEITLQP AVVVDTTDVT VTVVGEAPTM TTGETPTAFT SSGSDPKGQQ VLKLGVGEGQ 
3001:	YPGTNPQRAS LHEAIQGADE RPSVLILGSD KATSNRVKTA KNVKVYRGRD PLEVRDMMRR 
3061:	GKILVIALSK VDNALLKFVD YKGTFLTRET LEALSLGRPK KKDITKAEAQ WLLCLEDQTE 
3121:	ELPDWFAAGE PIFLEANIKH DRYHLVGDIA TIKEKAKQLG ATDSTKISKE VGAKVYSMKL 
3181:	SNWVMQEENK QGNLTPLFEE LLQQCPPGGQ NKTAHMVSAY QLAQGNWMPT SCHVFMGTIS 
3241:	ARRTKTHPYE AYVKLRELIE EHKMKTLCPG SSLGKHNEWI IGKIKYQGNL RTKHMLNPGK 
3301:	VAEQLCREGH RHNVYNKTIG SVMTATGIRL EKLPVVRAQT DTTNFHQAIR DKIDKEENLQ 
3361:	TPGLHKKLME VFNALKRPEL ESSYDAVEWE ELERGINRKG AAGFFERKNI GEILDSEKNK 
3421:	VEEIIDNLKK GRNIKYCETA IPKNEKRDVN DDWTAGDFVD EKKPRVIQYP EAKTRLAITK 
3481:	VMYKWVKQKP VVIPGYEGKT PLFQIFDKVK REWDQFQNPV AVSFDTKAWD TQVTTKDLEL 
3541:	IMDIQKYYFK KKWHKFIDTL TMHMTEVPVI CADGEVYIRK GQRGSGQPDT SAGNSMLNVL 
3601:	TMVYAFCEAT GVPYKSFDRV AKIHVCGDDG LLITERALGE KFASKGVQIL YEAGKPQKIT 
3661:	EGDKMKVAYQ FDDIEFCSHT PIQVRWSDNT SSYMPGRNTT TILAKMATRL DSSGERGTIA 
3721:	CEKAVAFSFL LMYSWNPLIR RICLLVLSTE LQVKPGKSTT YYYEGDPISA YKEVIGHNLL 
3781:	DLKRTSFEKL AKLNLSMSVL GAWTRHTSKR LLQDCVNMGV KEGNWLVNAD RLVSSKTGNR 
3841:	YIPGEGHTLQ GRHYEELVLA RKQINNFQGA DRYNLGPIVD MVLRRLRVMM MTLIGRGV