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1.A.53.1.5
The borine viral diarrhea virus (BVDV) p7 peptide, viral budding process initiator.

Accession Number:Q96662
Protein Name:Genome polyprotein
Length:3907
Molecular Weight:439104.00
Species:Bovine viral diarrhea virus (strain CP7) (BVDV) [268305]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Host membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

Pfam: PF11889    PF07652    PF00271    PF05550    PF12387    PF05578    PF00998   

Gene Ontology

GO:0033644 C:host cell membrane
GO:0044228 C:host cell surface
GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0008026 F:ATP-dependent helicase activity
GO:0004197 F:cysteine-type endopeptidase activity
GO:0005216 F:ion channel activity
GO:0033897 F:ribonuclease T2 activity
GO:0003723 F:RNA binding
GO:0003968 F:RNA-directed RNA polymerase activity
GO:0004252 F:serine-type endopeptidase activity
GO:0070008 F:serine-type exopeptidase activity
GO:0030683 P:evasion by virus of host immune response
GO:0006508 P:proteolysis
GO:0006351 P:transcription, DNA-dependent
GO:0019079 P:viral genome replication
GO:0019082 P:viral protein processing

References (7)

[1] “Recovery of cytopathogenic and noncytopathogenic bovine viral diarrhea viruses from cDNA constructs.”  Meyers G.et.al.   8970985
[2] “Mutations in the 5' nontranslated region of bovine viral diarrhea virus result in altered growth characteristics.”  Becher P.et.al.   10933696
[3] “Processing in the pestivirus E2-NS2 region: identification of proteins p7 and E2p7.”  Elbers K.et.al.   8648755
[4] “Serine protease of pestiviruses: determination of cleavage sites.”  Tautz N.et.al.   9188613
[5] “E2-p7 region of the bovine viral diarrhea virus polyprotein: processing and functional studies.”  Harada T.et.al.   11000219
[6] “Temporal modulation of an autoprotease is crucial for replication and pathogenicity of an RNA virus.”  Lackner T.et.al.   15367643
[7] “The pestivirus glycoprotein Erns is anchored in plane in the membrane via an amphipathic helix.”  Tews B.A.et.al.   17848558
Structure:
2AJJ   2AJM   2AJN   2AJO   2CJQ   4DVK   4DVL   4DVN   4DW3   4DW4   [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MELITNELLY KTYKQKPAGV EEPVYDQAGN PLFGERGVIH PQSTLKLPHK RGEREVPTNL 
61:	ASLPKRGDCR SGNSKGPVSG IYLKPGPLFY QDYKGPVYHR APLEFFEEAS MCETTKRIGR 
121:	VTGSDSRLYH IYVCIDGCII VKSATKDRQK VLKWVHNKLN CPLWVSSCSD TKDEGVVRKK 
181:	QQKPDRLEKG RMKITPKESE KDSKTKPPDA TIVVDGVKYQ VKKKGKVKSK NTQDGLYHNK 
241:	NKPQESRKKL EKALLAWAII ALVFFQVTMG ENITQWNLQD NGTEGIQRAM FQRGVNRSLH 
301:	GIWPEKICTG VPSHLATDTE LKAIHGMMDA SEKTNYTCCR LQRHEWNKHG WCNWYNIEPW 
361:	ILLMNKTQAN LTEGQPLREC AVTCRYDRDS DLNVVTQARD SPTPLTGCKK GKNFSFAGIL 
421:	VQGPCNFEIA VSDVLFKEHD CTSVIQDTAH YLVDGMTNSL ESARQGTAKL TTWLGRQLGI 
481:	LGKKLENKSK TWFGAYAASP YCEVERKLGY IWYTKNCTPA CLPRNTKIIG PGRFDTNAED 
541:	GKILHEMGGH LSEVLLLSVV VLSDFAPETA SVIYLILHFS IPQGHTDIQD CDKNQLNLTV 
601:	ELTTAEVIPG SVWNLGKYVC VRPDWWPYET ATVLVIEEVG QVIKVVLRAL KDLTRIWTAA 
661:	TTTAFLVCLV KVVRGQVLQG ILWLMLITGA QGYPDCKPGF SYAIAKNDEI GPLGATGLTT 
721:	QWYEYSDGMR LQDSVVEVWC KNGEIKYLIR CGREARYLAV LHTRALPTSV VFEKIFDGKE 
781:	QEDIVEMDDN FEFGLCPCDA RPLIRGKFNT TLLNGPAFQM VCPIGWTGTV SCTLANKDTL 
841:	ATIVVRTYKR VRPFPYRQDC VTQKTIGEDL YDCALGGNWT CVPGDALRYV AGPVESCEWC 
901:	GYKFLKSEGL PHFPIGKCRL KNESGYRQVD ETSCNRNGVA IVPSGTVKCK IGDTVVQVIA 
961:	MDDKLGPMPC KPHEIISSEG PVEKTACTFN YTRTLKNKYF EPRDNYFQQY MLKGEYQYWF 
1021:	DLEITDHHRD YFAESLLVIV VALLGGRYVL WLLVTYMILS EQMASGVQYG AGEIVMMGNL 
1081:	LTHDSVEVVT YFLLLYLLLR EENTKKWVIL IYHIIVMHPL KSVTVILLMV GGMAKAEPGA 
1141:	QGYLEQVDLS FTMITIIVIG LVIARRDPTV VPLVTIVAAL KITGLGFGPG VDAAMAVLTL 
1201:	TLLMTSYVTD YFRYKRWIQC ILSLVAGVFL IRTLKHLGEL KTPELTIPNW RPLTFILLYL 
1261:	TSATVVTRWK IDIAGIFLQG APILLMIATL WADFLTLVLI LPTYELAKLY YLKNVKTDVE 
1321:	KSWGVPYPDP QTLGGLDYRT IDSVYDVDES GEGVYLFPSR QKKNKNISIL LPLIRATLIS 
1381:	CISSKWQMVY MAYLTLDFMY YMHRKVIEEI SGSTNVMSRV IAALIELNWS MEEEESKGLK 
1441:	KFFILSGRLR NLIIKHKVRN QTVASWYGEE EVYGMPKVVT IIRACTLNKN KHCIICTVCE 
1501:	ARKWKGGNCP KCGRHGKPII CGMTLADFEE RHYKRIFIRE GNFEGPFRQE YNGFVQYTAR 
1561:	GQLFLRNLPI LATKVKMIMV GNLGEEIGDL EHLGWILRGP AVCKKITEHE KCHVNILDKL 
1621:	TAFFGVMPRG TTPRAPVRFP TALLKVRRGL ETGWAYTHQG GISSVDHVTA GKDLLVCDSM 
1681:	GRTRVVCQSN NKLTDETEYG VKTDSGCPDG ARCYVLNPEA VNISGSKGAV VHLQKTGGEF 
1741:	TCVTASGTPA FFDLKNLKGW SGLPIFEASS GRVVGRVKVG KNEESKPTKL MSGIQTVSKN 
1801:	TADLTEMVKK ITSMNRGDFR QITLATGAGK TTELPKAVIE EIGRHKRVLV LIPLRAAAES 
1861:	VYQYMRLKHP SISFNLRIGD MKEGDMATGI TYASYGYFCQ MPQPKLRAAM IEYSYIFLDE 
1921:	YHCATPEQLA VIGKIHRFSE SIRVVAMTAT PAGSVTTTGQ KHPIEEFIAP EVMKGEDLGS 
1981:	QFLDIAGLKI PVEEMKGNML VFVPTRNMAV EVAKKLKAKG YNSGYYYSGE DPANLRVVTS 
2041:	QSPYVVVATN AIESGVTLPD LDTVVDTGLK CEKRVRVSSK IPFIVTGLKR MAVTVGEQAQ 
2101:	RRGRVGRVKP GRYYRSQETA TGSKDYHYDL LQAQRYGIED GINVTKSFRE MNYDWSLYEE 
2161:	DSLLITQLEI LNNLLISEDL PAAVKNIMAR TDHPEPIQLA YNSYEVQVPV LFPKIRNGEV 
2221:	TDTYENYSFL NARKLGEDVP VYVYATEDED LAVDLLGLDW PDPGNQQVVE TGKALKQVVG 
2281:	LSSAENALLI ALFGYVGYQA LSKRHVPMIT DIYTIEDQRL EDTTHLQYAP NAIRTEGKET 
2341:	ELKELAVGDL DKIMGSISDY ASEGLNFVRS QAEKMRSAPA FKENVEAAKG YVQKFIDSLI 
2401:	ENKETIIRYG LWGTHTALYK SIAARLGHET AFATLVIKWL AFGGESVSDH MRQAAVDLVV 
2461:	YYVINKPSFP GDSETQQEGR RFVASLFISA LATYTYKTWN YNNLSKVVEP ALAYLPYATN 
2521:	ALKMFTPTRL ESVVILSTTI YKTYLSIRKG KSDGLLGTGI SAAMEILSQN PVSVGISVML 
2581:	GVGAIAAHNA IESSEQKRTL LMKVFVKNFL DQAATDELVK ENPEKIIMAL FEAVQTIGNP 
2641:	LRLIYHLYGV YYKGWEAKEL SERTAGRNLF TLIMFEAFEL LGMDSEGKIR NLSGNYVLDL 
2701:	IYSLHKQINR GLKKIVLGWA PAPFSCDWTP SDERIRLPTN NYLRVETKCP CGYEMKALRN 
2761:	VGGSLTKVEE KGPFLCRNRL GRGPVNYRVT KYYDDNLKEI KPVAKLEGFV DHYYKGVTAR 
2821:	IDYGRGKMLL ATDKWEVEHG VVTRLAKRYT GVGFKGAYLG DEPNHRDLVE RDCATITKNT 
2881:	VQFLKMKKGC AFTYDLTLSN LTRLIELVHK NNLEEKDIPA ATVTTWLAYT FVNEDIGTIK 
2941:	PVLGERVVTD PVVDVNLQPE VQVDTSEVGI TLVGRAALMT TGTTPVVEKT EPNADGGPSS 
3001:	IKIGLDEGRY PGPGLQDRTL TDEIHSRDER PFVLVLGSKN SMSNRAKTAR NINLYKGNNP 
3061:	REIRDLMAQG RMLVVALKDF NPELSELVDF KGTFLDREAL EALSLGRPKS KQVTTATVRE 
3121:	LLEQEVQVEI PSWFGAGDPV FLEVTLKGDR YHLVGDVDRV KDQAKELGAT DQTRIVKEVG 
3181:	ARTYTMKLSS WFLQATNKQM SLTPLFEELL LRCPPKIKSN KGHMASAYQL AQGNWEPLDC 
3241:	GVHLGTIPAR RVKIHPYEAY LKLKDLLEEE EKKPKCRDTV IREHNKWILK KVRHQGNLNT 
3301:	KKILNPGKLS EQLDREGHKR NIYNNQIGTI MTEAGSRLEK LPVVRAQTDT KSFHEAIRDK 
3361:	IDKNENQQSP GLHDKLLEIF HTIAQPSLRH TYSDVTWEQL EAGVNRKGAA GFLEKKNVGE 
3421:	VLDSEKHLVE QLIRDLKTGR KIRYYETAIP KNEKRDVSDD WQSGDLVDEK KPRVIQYPEA 
3481:	KTRLAITKVM YNWVKQQPVV IPGYEGKTPL FNIFNKVRKE WDLFNEPVAV SFDTKAWDTQ 
3541:	VTSRDLRLIG EIQKYYYRKE WHKFIDTITD HMVEVPVITA DGEVYIRNGQ RGSGQPDTSA 
3601:	GNSMLNVLTM MYAFCESTGV PYKSFNRVAR IHVCGDDGFL ITEKGLGLKF ANNGMQILHE 
3661:	AGKPQKITEG ERMKVAYRFE DIEFCSHTPV PVRWSDNTSS YMAGRDTAVI LSKMATRLDS 
3721:	SGERGTIAYE KAVAFSFLLM YSWNPLVRRI CLLVLSQQPE TTPSTQTTYY YKGDPIGAYK 
3781:	DVIGKNLCEL KRTGFEKLAN LNLSLSTLGI WSKHTSKRII QDCVTIGKEE GNWLVNADRL 
3841:	ISSKTGHLYI PDKGYTLQGK HYEQLQLQAR TSPVTGVGTE RYKLGPIVNL LLRRLRVLLM 
3901:	AAVGASS