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1.A.54.2.1
Archaeal presenilin homologue (DUF1119; COG3389; PSN). Members of the peptidase A22B superfamily (found in many archaea, but not bacteria, shows some sequence similarity to members of the LIV-E family, e.g., 2.A.78.2.1))

Accession Number:Q18K19
Protein Name:PSN aka HQ1505A
Length:339
Molecular Weight:35728.00
Species:Haloquadratum walsbyi (strain DSM 16790) [362976]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

eggNOG: arNOG05497
HEGENOM: HBG497923
RefSeq: YP_657277.1   
Entrez Gene ID: 4192339   
Pfam: PF06550   
BioCyc: HWAL362976:HQ1505A-MONOMER   
KEGG: hwa:HQ1505A   

Gene Ontology

GO:0016021 C:integral to membrane

References (1)

[1] “The genome of the square archaeon Haloquadratum walsbyi: life at the limits of water activity.”  Bolhuis H.et.al.   16820047

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MHRRVAFGIG FTAVLFFLIQ LGALALVPTF YEQGYQTVED PTNPTNSLLY IGAILVATAV 
61:	MLAAFKYELQ WLVKGFITLA AGSLAWYVFS VFFSPLLAAI PAVGLAVLLI IYPEWYIIDA 
121:	AGVLMGAGAA GLFGISFGLL PALVLLSILA VYDAISVYGT EHMLDLAAGV MDLNLPVILV 
181:	IPTTLSYSLR EDVSPVATDD NTNVSVSDNE THTHANELAE HDAETPSSID ETSTDDSHIR 
241:	DAFFIGLGDA VMPTVLVASA AFFLPGELTP SLGIFGIPAM TLPALTAMIG TFIGLFVLMW 
301:	LVVKGRAHAG LPLLNGGAIG GYLIGALLSG VPLIRALGL