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1.A.54.3.1
Signal peptide peptidase-2A (SPP2A; 523 aas; 8TMSs) (no evidence for a transport function).

Accession Number:Q9JJF9
Protein Name:Signal peptide peptidase-like 2A
Length:523
Molecular Weight:58071.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: Q9JJF9
HEGENOM: HBG713902
Entrez Gene ID: 66552   
Pfam: PF02225    PF04258   
KEGG: mmu:66552   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0004190 F:aspartic-type endopeptidase activity

References (1)

[1] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGLLHSLHAP AAALLWSCLL GLAAAQEAIL HASTNGVSSL SKDYCMYYNN NWTRLPSSLE 
61:	NATSLSLMNL TGTALCHLSD IPPDGIRNKA VVVHWGPCHF LEKARIAQEG GAAALLIANN 
121:	SVLIPSSRNK STFQNVTVLI AVITQKDFKD MKETLGDDIT VKMYSPSWPN FDYTLVVIFV 
181:	IAVFTVALGG YWSGLIELEN MKSVEDAEDR ETRKKKDDYL TFSPLTVVVF VVICCIMIVL 
241:	LYFFYRWLVY VMIAIFCIAS SMSLYNCLSA LIHRMPCGQC TILCCGKNIK VSLIFLSGLC 
301:	ISVAVVWAVF RNEDRWAWIL QDILGIAFCL NLIKTMKLPN FMSCVILLGL LLIYDVFFVF 
361:	ITPFITKNGE SIMVELAAGP FENAEKLPVV IRVPKLMGYS VMSVCSVPVS VLGFGDIIVP 
421:	GLLIAYCRRF DVQTGSSIYY ISSTIAYAVG MIITFVVLMV MKTGQPALLY LVPCTLITVS 
481:	VVAWSRKEMK KFWKGSSYQV MGHLDYSTNE ENPVTTDEQI VQQ