TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.54.4.1
The pre-flagelin peptidase of 230 aas and 6 TMSs, FlaK, with known 3-d structure (3.6Å resolution) (Hu et al. 2011).  This protein is a member of the presenilin/GxGD membrane protein family; it plays a dual role as protease and ion-conducting channel and is therefore called a "channzyme" (Kuo et al. 2015).

Accession Number:Q6LZR9
Protein Name:Preflagellin peptidase
Length:230
Molecular Weight:25915.00
Species:Methanococcus maripaludis (strain S2 / LL) [267377]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate ions

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MIEYIIGVIG LLLASVQDFR SREIEDYIWI VLAVFGILFA IYSAITLSNY SILINSISGF 
61:	VICFILGYMM FLSGIGGGDG KILIGLGALV PKFQMPIYTS LGTLLNLNYI PNFPIMVFIN 
121:	GIFFMVFLPF VILFRNILNG ARPKTGKEVI LMFFGEKMKV KVAKEQKRLI MGQNDKINFF 
181:	PASDDEDFSK YGDEEEIWVT PQIPLIIPIT LSYLVTPIIG DRILDLLIPF