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Accession Number: | O15431 |
Protein Name: | COP1 aka hCTR1 aka SLC31A1 aka CTR1 aka COPT1 |
Length: | 190 |
Molecular Weight: | 21091.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 3 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | Cu+, Ag+ |
Cross database links:
Genevestigator: | O15431 O15431 |
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eggNOG: | prNOG17043 NOG323808 |
HEGENOM: | HBG715469 HOG000195393 |
RefSeq: | NP_001850.1 |
Entrez Gene ID: | 1317 |
Pfam: | PF04145 |
OMIM: |
603085 gene |
KEGG: | hsa:1317 hsa:1317 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0005375
F:copper ion transmembrane transporter activity
GO:0006825
P:copper ion transport
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References (15)[1] “hCTR1: a human gene for copper uptake identified by complementation in yeast.” Zhou B.et.al. 9207117 [2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [3] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 [4] “DNA sequence and analysis of human chromosome 9.” Humphray S.J.et.al. 15164053 [5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [6] “O-linked glycosylation at threonine 27 protects the copper transporter hCTR1 from proteolytic cleavage in mammalian cells.” Maryon E.B.et.al. 17525160 [7] “Projection structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture.” Aller S.G.et.al. 16501047 [8] “hCTR1: a human gene for copper uptake identified by complementation in yeast.” Zhou B.et.al. 9207117 [9] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [10] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 [11] “DNA sequence and analysis of human chromosome 9.” Humphray S.J.et.al. 15164053 [12] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [13] “Biochemical characterization of the human copper transporter Ctr1.” Lee J.et.al. 11734551 [14] “O-linked glycosylation at threonine 27 protects the copper transporter hCTR1 from proteolytic cleavage in mammalian cells.” Maryon E.B.et.al. 17525160 [15] “Projection structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture.” Aller S.G.et.al. 16501047
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Structure: | |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MDHSHHMGMS YMDSNSTMQP SHHHPTTSAS HSHGGGDSSM MMMPMTFYFG FKNVELLFSG 61: LVINTAGEMA GAFVAVFLLA MFYEGLKIAR ESLLRKSQVS IRYNSMPVPG PNGTILMETH 121: KTVGQQMLSF PHLLQTVLHI IQVVISYFLM LIFMTYNGYL CIAVAAGAGT GYFLFSWKKA 181: VVVDITEHCH