TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.56.1.3
Vacuolar copper transporter (exports Cu+ from the vacuole to the cytoplasm; acts with Fre6 (Q12473: TC# 5.B.1.7.1) (metalo-reductase that reduces Cu2+ to Cu+ in the vacuole) (Rees and Thiele, 2007).

Accession Number:P38865
Protein Name:CTR2 aka Ctr2p aka YHR175W
Length:189
Molecular Weight:21651.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate Cu+

Cross database links:

Genevestigator: P38865
eggNOG: fuNOG11334
HEGENOM: HBG715469
DIP: DIP-4763N
RefSeq: NP_012045.1   
Entrez Gene ID: 856580   
Pfam: PF04145   
KEGG: sce:YHR175W   

Gene Ontology

GO:0000329 C:fungal-type vacuole membrane
GO:0016021 C:integral to membrane
GO:0015088 F:copper uptake transmembrane transporter act...
GO:0042802 F:identical protein binding
GO:0015677 P:copper ion import
GO:0015680 P:intracellular copper ion transport

References (4)

[1] “Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII.”  Johnston M.et.al.   8091229
[2] “Molecular characterization of a putative Arabidopsis thaliana copper transporter and its yeast homologue.”  Kampfenkel K.K.K.et.al.   7499355
[3] “Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter.”  Rees E.M.et.al.   15494390
[4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MDDKKTWSTV TLRTFNQLVT SSLIGYSKKM DSMNHKMEGN AGHDHSDMHM GDGDDTCSMN 
61:	MLFSWSYKNT CVVFEWWHIK TLPGLILSCL AIFGLAYLYE YLKYCVHKRQ LSQRVLLPNR 
121:	SLTKINQADK VSNSILYGLQ VGFSFMLMLV FMTYNGWLML AVVCGAIWGN YSWCTSYSPE 
181:	IDDSSLACH