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1.A.56.1.9
Probable low affinity copper uptake protein 2 (Ctr2) (present in the plasma membrane and interbal membranes where it stimulates copper uptake into the cytoplasm) (Bertinato et al., 2007; Wee et al. 2013).

Accession Number:O15432
Protein Name:Ctr2
Length:143
Molecular Weight:15681.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Cu+

Cross database links:

HOG000195393
Genevestigator: O15432 O15432
eggNOG: prNOG16177 NOG317287
RefSeq: NP_001851.1   
Entrez Gene ID: 1318   
Pfam: PF04145   
OMIM: 603088  gene
KEGG: hsa:1318    hsa:1318   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005375 F:copper ion transmembrane transporter activity
GO:0006825 P:copper ion transport

References (4)

[1] “hCTR1: a human gene for copper uptake identified by complementation in yeast.”  Zhou B.et.al.   9207117
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “hCTR1: a human gene for copper uptake identified by complementation in yeast.”  Zhou B.et.al.   9207117
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAMHFIFSDT AVLLFDFWSV HSPAGMALSV LVLLLLAVLY EGIKVGKAKL LNQVLVNLPT 
61:	SISQQTIAET DGDSAGSDSF PVGRTHHRWY LCHFGQSLIH VIQVVIGYFI MLAVMSYNTW 
121:	IFLGVVLGSA VGYYLAYPLL STA