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1.A.56.2.1
Plasma membrane high affinity copper transporter, Ctr1p (Puig et al., 2002); acts with Fre1 (P32791: TC# 5.B.1.5.1) (metalo-reductase that reduces Cu2+ to Cu+ at the cell surface (Rees and Thiele, 2007).

Accession Number:P49573
Protein Name:CTR1 aka Ctr1p aka YPR124W aka P9642.3
Length:406
Molecular Weight:44442.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Cu+

Cross database links:

Genevestigator: P49573
eggNOG: fuNOG09911
HEGENOM: HBG203994
DIP: DIP-6447N
RefSeq: NP_015449.1   
Entrez Gene ID: 856241   
Pfam: PF04145   
KEGG: sce:YPR124W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005624 C:membrane fraction
GO:0005886 C:plasma membrane
GO:0015088 F:copper uptake transmembrane transporter act...
GO:0042802 F:identical protein binding
GO:0015677 P:copper ion import

References (8)

[1] “Molecular characterization of a copper transport protein in S. cerevisiae: an unexpected role for copper in iron transport.”  Dancis A.et.al.   8293472
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.”  Bussey H.et.al.   9169875
[3] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[4] “The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake.”  Dancis A.et.al.   7929270
[5] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[6] “Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.”  Li X.et.al.   17330950
[7] “Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.”  Smolka M.B.et.al.   17563356
[8] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEGMNMGSSM NMDAMSSASK TVASSMASMS MDAMSSASKT ILSSMSSMSM EAMSSASKTL 
61:	ASTMSSMASM SMGSSSMSGM SMSMSSTPTS SASAQTTSDS SMSGMSGMSS SDNSSSSGMD 
121:	MDMSMGMNYY LTPTYKNYPV LFHHLHANNS GKAFGIFLLF VVAAFVYKLL LFVSWCLEVH 
181:	WFKKWDKQNK YSTLPSANSK DEGKHYDTEN NFEIQGLPKL PNLLSDIFVP SLMDLFHDII 
241:	RAFLVFTSTM IIYMLMLATM SFVLTYVFAV ITGLALSEVF FNRCKIAMLK RWDIQREIQK 
301:	AKSCPGFGNC QCGRHPEPSP DPIAVADTTS GSDQSTRLEK NNESKVAISE NNQKKTPTQE 
361:	EGCNCATDSG KNQANIERDI LENSKLQEQS GNMDQNLLPA EKFTHN