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1.A.57.1.1
SARS-CoV Viroporin tetrameric ion channel. Protein 3a is of 274 aas and 3 TMSs.

Accession Number:P59632
Protein Name:SARS-Caronavirus aka Viroporin aka Protein 3a
Length:274
Molecular Weight:30903.00
Species:Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) [227859]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Virion1 / Multi-pass membrane protein2
Substrate ions

Cross database links:

Gene Ontology

GO:0044178 C:host cell Golgi membrane
GO:0020002 C:host cell plasma membrane
GO:0016021 C:integral to membrane
GO:0019012 C:virion
GO:0006915 P:apoptosis

References (14)

[1] “Characterization of a novel coronavirus associated with severe acute respiratory syndrome.”  Rota P.A.et.al.   12730500
[2] “The genome sequence of the SARS-associated coronavirus.”  Marra M.A.et.al.   12730501
[3] “Coronavirus genomic-sequence variations and the epidemiology of the severe acute respiratory syndrome.”  Tsui S.K.W.et.al.   12853594
[4] “The complete genome sequence of severe acute respiratory syndrome coronavirus strain HKU-39849 (HK-39).”  Zeng F.Y.et.al.   12876307
[5] “Identification of a novel protein 3a from severe acute respiratory syndrome coronavirus.”  Yu C.-J.et.al.   15135062
[6] “A novel severe acute respiratory syndrome coronavirus protein, U274, is transported to the cell surface and undergoes endocytosis.”  Tan Y.-J.et.al.   15194747
[7] “Subcellular localization and membrane association of SARS-CoV 3a protein.”  Yuan X.et.al.   15763150
[8] “The severe acute respiratory syndrome coronavirus 3a is a novel structural protein.”  Shen S.et.al.   15781262
[9] “Severe acute respiratory syndrome coronavirus 3a protein is a viral structural protein.”  Ito N.et.al.   15709039
[10] “The severe acute respiratory syndrome coronavirus 3a protein up-regulates expression of fibrinogen in lung epithelial cells.”  Tan Y.J.et.al.   16014971
[11] “The 3a protein of severe acute respiratory syndrome-associated coronavirus induces apoptosis in Vero E6 cells.”  Law P.T.et.al.   15958670
[12] “Glycosylation of the severe acute respiratory syndrome coronavirus triple-spanning membrane proteins 3a and M.”  Oostra M.et.al.   16474139
[13] “Severe acute respiratory syndrome coronavirus 3a protein is released in membranous structures from 3a protein-expressing cells and infected cells.”  Huang C.et.al.   16352545
[14] “Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release.”  Lu W.et.al.   16894145

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDLFMRFFTL GSITAQPVKI DNASPASTVH ATATIPLQAS LPFGWLVIGV AFLAVFQSAT 
61:	KIIALNKRWQ LALYKGFQFI CNLLLLFVTI YSHLLLVAAG MEAQFLYLYA LIYFLQCINA 
121:	CRIIMRCWLC WKCKSKNPLL YDANYFVCWH THNYDYCIPY NSVTDTIVVT EGDGISTPKL 
181:	KEDYQIGGYS EDRHSGVKDY VVVHGYFTEV YYQLESTQIT TDTGIENATF FIFNKLVKDP 
241:	PNVQIHTIDG SSGVANPAMD PIYDEPTTTT SVPL