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1.A.6.1.3
The epithelial Na+ channel, EnaC5 (involved in fluid and electrolyte homeostasis). The C-terminus of each subunit (α, β, and γ) contains a PPXY motif for interaction with the WW domains of the ubiquitin-protein ligases, Nedd4 and Nedd4-2. Disruption of this interaction, as in Liddle's syndrome where mutations delete or alter the PPXY motif of either the β or γ subunits, has been shown to result in increased ENaC activity and arterial hypertension. N4WBP5A (Nedd4-family interacting protein-2) plays a role (see 8.A.30; Konstas et al., 2002). Wiemuth & Grunder (2010) showed that an unknown ligand, interacting with an amino acyl residue in the extracellular domain, tunes Ca2+ inhibition in the rat protein, but not the mouse orthologue.

Accession Number:Q9R0W5
Protein Name:Amiloride-sensitive Na+ channel aka Accn5 aka BLINaC aka ENaC5
Length:495
Molecular Weight:56464.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

Genevestigator: Q9R0W5
eggNOG: roNOG11861
RefSeq: NP_071563.1   
Entrez Gene ID: 63866   
Pfam: PF00858   
KEGG: rno:63866   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015280 F:amiloride-sensitive sodium channel activity
GO:0006814 P:sodium ion transport

References (1)

[1] “Cloning and functional expression of a novel degenerin-like Na+ channel gene in mammals.”  Sakai H.et.al.   10457052

External Searches:

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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEHTEKSKGP AEKGLLGKIR RYLSKRPLPS PTDRKKFDHD FAISTSFHGI HNIAQNQNKV 
61:	RKVIWLSVVL GSVSLLVWQI YSRLVNYFMW PTTTSIEVQY VEKIEFPAVT FCNLNRFQTE 
121:	AVSRFGIIFF LWDIVSKVLR LQEISGNNTG SPEALDFVAS HRNFSITEFV KNNGFYLNHD 
181:	TLVHCEFFGK TCDPKDFKHV FTEYGNCFTF NYGENVQSKN KVSVSGRGLK LLLDVHQEEF 
241:	TDNPVPGFAD AGVIFVIHSP KKEPQFDGLG LSSPVGMHAR VTIRQLKTIH QEYPWGECNP 
301:	DIKLRNFTTY STYGCLKECK AKHIQRLCGC LPFLLPGNGV ECDLLKYYNC VSPILDHIER 
361:	KGLCTMGTHN SSCPVPCEET EYPATIAYST FPSQRATKFL AKKLNQSQEY IRENLVNIEI 
421:	NYSDLNYKIT QQQKAVSVPE LLADVGGQLG LFCGASLITI IEIIEYLFTS FYWVFIFFLL 
481:	KILEMIQRTS PPQTV