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1.A.6.1.5
Neuronal acid-sensing cation channel-1, ASIC1 (>90% identical to ASIC1 of Rat (TC#1.A.6.1.2)). 3D structure (1.9Å resolution) has been solved (Jasti et al., 2007). Regulated by the glucocorticoid-induced kinase-1 isoform 1 (SGK1.1) (Arteaga et al., 2008). Residues in the second transmembrane domain of the ASIC1a that contribute to ion selectivity have been defined (Carattino and Della Vecchia, 2012). Outlines of the pore in open and closed conformations describe the gating mechanism (Li et al., 2011). Interactions between two extracellular linker regions control sustained channel opening (Springauf et al., 2011).  Can form monomers, trimers and tetramers, but the tetramer may be the predominant species in the plasma membrane (van Bemmelen et al. 2015).

Accession Number:Q1XA76
Protein Name:ASIC1
Length:527
Molecular Weight:60010.00
Species:Gallus gallus (Chicken) [9031]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

eggNOG: veNOG06617
RefSeq: NP_001035557.1   
Entrez Gene ID: 426883   
Pfam: PF00858   
KEGG: gga:426883   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015280 F:amiloride-sensitive sodium channel activity
GO:0006814 P:sodium ion transport

References (3)

[1] “Proton sensitivity of ASIC1 appeared with the rise of fishes by changes of residues in the region that follows TM1 in the ectodomain of the channel.”  Coric T.et.al.   16002453
[2] “Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH.”  Jasti J.et.al.   17882215
[3] “Pore architecture and ion sites in acid-sensing ion channels and P2X receptors.”  Gonzales E.B.et.al.   19641589
Structure:
2QTS   3HGC   3IJ4   3S3W   3S3X   4FZ0   4FZ1   4NTW   4NTX   4NTY   [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMDLKVDEEE VDSGQPVSIQ AFASSSTLHG ISHIFSYERL SLKRVVWALC FMGSLALLAL 
61:	VCTNRIQYYF LYPHVTKLDE VAATRLTFPA VTFCNLNEFR FSRVTKNDLY HAGELLALLN 
121:	NRYEIPDTQT ADEKQLEILQ DKANFRNFKP KPFNMLEFYD RAGHDIREML LSCFFRGEQC 
181:	SPEDFKVVFT RYGKCYTFNA GQDGKPRLIT MKGGTGNGLE IMLDIQQDEY LPVWGETDET 
241:	SFEAGIKVQI HSQDEPPLID QLGFGVAPGF QTFVSCQEQR LIYLPPPWGD CKATTGDSEF 
301:	YDTYSITACR IDCETRYLVE NCNCRMVHMP GDAPYCTPEQ YKECADPALD FLVEKDNEYC 
361:	VCEMPCNVTR YGKELSMVKI PSKASAKYLA KKYNKSEQYI GENILVLDIF FEALNYETIE 
421:	QKKAYEVAGL LGDIGGQMGL FIGASILTVL ELFDYAYEVI KHRLCRRGKC RKNHKRNNTD 
481:	KGVALSMDDV KRHNPCESLR GHPAGMTYAA NILPHHPARG TFEDFTC