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1.A.6.1.6
Acid sensing cation channel ASIC4.1 (senses and gated by extracellular pH) (forms homomers and heteromers with ASIC4.2) (Chen et al., 2007)

Accession Number:Q708S4
Protein Name:ASIC4.1
Length:539
Molecular Weight:60814.00
Species:Danio rerio (Zebrafish) (Brachydanio rerio) [7955]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

eggNOG: fiNOG04835
RefSeq: NP_999952.1   
Entrez Gene ID: 407668   
Pfam: PF00858   
KEGG: dre:407668   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0015280 F:amiloride-sensitive sodium channel activity
GO:0006814 P:sodium ion transport

References (1)

[1] “A family of acid-sensing ion channels (ASICs) from the zebrafish: widespread e xpression in the central nervous system suggests a conserved role in neuronal communication.”  Paukert M.et.al.   14970195

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPIEFVCKIK FAEEDEKQKG NQDGDKESLI EESCSPPTKD LAGFASASSL HGINHIFVSG 
61:	RLGVRQTLWA LAFLVSLALF LYQAAKCAIS YLEHPHVTAL NEEATPEMVF PAVTICNINR 
121:	FRFSALTDAD IYHLANLTGL PPKNKDGHKP TDLEYPAPDM QDIFNRTGHQ LEEMLKSCNF 
181:	SGQNCSAEDF TVVYTRYGKC YTFNGNKTTS RKTKQGGMGN GLEIMLDIQQ DDYLPIWKET 
241:	NETSLEAGIR VQIHSQDEPP YIHQLGFGVS PGFQTFVSCQ EQRLTYLPQP WGNCRSTSEQ 
301:	MIPGYDTYSI SACRLRCETL EVLRECKCRM VHMPGDANIC TPSDIKCVDK ALALLQKSSG 
361:	DTCFCETPCN LTRYGKELSM VKIPSKGSAR YLSRKYDKSE DYIRDNFLVL DIFFEALNYE 
421:	TIEQKKAYDV AGLLGDIGGQ MGLFIGASVL TILEILDYVY EVIKHRLERL LRPQRDDKKQ 
481:	TQQQQQASTV ATVNLEEMKA KDSSEMSRSH SEGAYANTIL PNHHHHHRTH HRVSEDFAC