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1.A.6.1.7
Acid sensing cation channel ASIC4.2 (does not sense extracellular pH) (forms homomers and heteromers with ASIC4.1) (Chen et al., 2007).

Accession Number:Q708S3
Protein Name:ASIC4.2
Length:558
Molecular Weight:62448.00
Species:Danio rerio (Zebrafish) (Brachydanio rerio) [7955]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

HEGENOM: HBG447044
RefSeq: NP_999951.1   
Entrez Gene ID: 407667   
Pfam: PF00858   
KEGG: dre:407667   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005272 F:sodium channel activity
GO:0006814 P:sodium ion transport

References (1)

[1] “A family of acid-sensing ion channels (ASICs) from the zebrafish: widespread e xpression in the central nervous system suggests a conserved role in neuronal communication.”  Paukert M.et.al.   14970195

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPIEFVCKIK FAEGEEAKGA STEGGGTGML DEGLRRQKEG MADLASFASS SSLHGLARAL 
61:	GTSERLGFRQ TLWGLALLVS LGLFLYQATW SAATYLERPH LAALREETRR ELTFPAITLC 
121:	NVNRFRFSAL TDADIYHLAN LTGLPPKSRK GHRPSELQYP PPNMLDIFQR TGHQLEDMLK 
181:	SCNFSGQNCS SEDFSVVYTR YGKCYTFNGN KTSPKRVRQG GTGNGLEMML DIQQDEYLPI 
241:	WRETNETTLE AGIRVQIHSQ NEPPYIHQLG FGVSPGFQTF VSCQEQRLTY LPQPWGNCRA 
301:	SSEPVIPGYD TYSVSACRLH CESTQVQREC NCRMVHMPGD ADICAPSKIK CVDKALASLQ 
361:	KSTGDSCPCE TPCNLTRYGK ELSMVKIPSR GSARYLSRKY QKSEEYIRDN FLILDIFFEA 
421:	LNYETIEQKK AYDIAGLLGD IGGQMGLFIG ASILTILEIL DYIYEVAKNK IKQLLKPKKS 
481:	QKQTNQRNLI QEQIQRTKNL REQNLKAQLT AGAIATVRFE EVKVKAANDV AQPHSAHPTS 
541:	VLPNHHNAQQ AVQQDFAC