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1.A.6.2.1
Degenerin-1

Accession Number:P24585
Protein Name:DEG1 aka C47C12.6 aka C47C12.1
Length:778
Molecular Weight:88127.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

eggNOG: meNOG13575
HEGENOM: HBG388583
RefSeq: NP_509311.1   
Entrez Gene ID: 181035   
Pfam: PF00858   
KEGG: cel:C47C12.6   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005272 F:sodium channel activity
GO:0008219 P:cell death
GO:0006814 P:sodium ion transport

References (3)

[1] “Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain.”  Garcia-Anoveros J.et.al.   7627559
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[3] “The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans.”  Chalfie M.et.al.   2342572

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSNHHSKTKK TSMLGREDYI YSHDITNKNK KEKLNGASKN NDYNQDDDDE TMKSKMMDFC 
61:	DKTTAHGAKR VLIARNSFSK LMWGLIIFSF LLMFAYQASK LIFKFSAHEK ITDISLKFDD 
121:	VEFPAITFCN LNPYKKSLVM MVPSIRDTMD VYDNAKTHSK SEGEKKKPKV SRKQHSDASQ 
181:	QMVRELFAKE IEEGMVELKK SNKTLQSQNK SGRRRSQRSI ENRRYEAIEA HCKCVGNIGM 
241:	ECIRFESPPR DPSSKCICTY DRDMEVAWPC FNISVWYDHE CPLCHDDGYC ESTLPSGTTS 
301:	SDKWPCMCRN RGDTSERDDT PYCIGKAGVG KIEIRKLWLE NNMTTTSTTT TTTTTPPPTT 
361:	TSTTTTTTTT PPPTTTARPN QRAIVSNPET IKAMGFQGMT DGVAMLTRAK ENLMFTMAAL 
421:	SDKQRIALSQ SKHEFIEMCS FNGKECDIDE DFRLHVDPEF GNCFTFNYDV NNNYTSSRAG 
481:	PMYGIRVLLF VNTSDYMSTS ESSGVRLAIH PPTEYPFPDT FGYSAPVGFA SSFGIKKKVM 
541:	QRLPAPYGEC VETKKVVDRN YIYAGYDYHP EGCHRSCFQN GLIDDCSCGD PRFPVPEGYR 
601:	HCSAFNATAR TCLEKNIGSV GDFHHITQKM DKCVCKQSCE EIIHEVTFSC SKWPSGATDL 
661:	GDCDGMTESE CEQYYRLNAA MIEVFYEQLN YELLQESEAY GLVNLIADFG GHLGLWLGFS 
721:	VITVMEVCVL LVDMISLFFK SRHEEKLLRQ STKRKDVPED KRQITVGSGR KSDAFVSI