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1.A.6.2.3
Degenerin channel, UNC-105. (Activated by degeneration or hypercontraction-causing mutations) (Bianchi, 2007; García-Añoveros et al., 1998)

Accession Number:Q09274
Protein Name:Degenerin-like protein unc-105
Length:887
Molecular Weight:100333.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

eggNOG: meNOG13575
HEGENOM: HBG380966
RefSeq: NP_001122595.1    NP_495702.1   
Entrez Gene ID: 174306   
Pfam: PF00858   
KEGG: cel:C41C4.5   

Gene Ontology

GO:0005272 F:sodium channel activity
GO:0006816 P:calcium ion transport
GO:0030154 P:cell differentiation
GO:0015693 P:magnesium ion transport
GO:0007517 P:muscle organ development
GO:0006814 P:sodium ion transport

References (8)

[1] “Interaction between a putative mechanosensory membrane channel and a collagen.”  Liu J.et.al.   8662524
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[3] “Mutations with dominant effects on the behavior and morphology of the nematode Caenorhabditis elegans.”  Park E.-C.et.al.   3744028
[4] “C. elegans unc-105 mutations affect muscle and are suppressed by other mutations that affect muscle.”  Park E.-C.et.al.   3744029
[5] “The nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations.”  Garcia-Anoveros J.et.al.   9655510
[6] “Patch clamp study of the UNC-105 degenerin and its interaction with the LET-2 collagen in Caenorhabditis elegans muscle.”  Jospin M.et.al.   15020702
[7] “An amiloride-sensitive H+-gated Na+ channel in Caenorhabditis elegans body wall muscle cells.”  Jospin M.et.al.   15254157
[8] “Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.”  Kaji H.et.al.   17761667

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAEDRIKSKL RRPASIESTM SSRTKPRHKP SPMSILMPHL MVGESFRKYR PHGLRNIRMN 
61:	GHLDWNQLRK SFEKQSTFHG ISHAATADGK WRWFWYTAFT ICLLALLIQI FFLISKYRQY 
121:	GKTVDLDLKF ENAPFPSITI CNLNPYKKSA IQSNPNTKAM MEAYSRRIGS GDKTEGIAAA 
181:	LSATGGLHAK VRRAKRKAKG KPRLRDRRYH QAFAQCLCDI EQLTGDRKGS CFAAFKGKIE 
241:	IDTNNTAGFM NLHTSRCLCQ LDTVSKALWP CFPYSSWKEK LCSECVDNTG HCPMRFYKGN 
301:	ELYENIKEQV DLCLCHKEYN HCVSTRDDGI ILEISPNDEL NDLDIGKKIA SQLSAQQEKQ 
361:	AEVTTTEAPT VTQALGFEEL TDDIAITSQA QENLMFAVGE MSEKAKESMS YELDELVLKC 
421:	SFNQKDCQMD RDFTLHYDNT FGNCYTFNYN RTAEVASHRA GANYGLRVLL YANVSEYLPT 
481:	TEAVGFRITV HDKHIVPFPD AFGYSAPTGF MSSFGVRMKQ FIRLEPPYGH CRHGGEDAAT 
541:	FVYTGFQYSV EACHRSCAQK VIVEACGCAD PMYPVAEMFG NNTKPCQAVN MDQRECLRNT 
601:	TLWLGELYSK GKEAIIPDCY CHQPCQETNY EVTYSSARWP SGSAKVMECL PGDFLCLEKY 
661:	RKNAAMVQIF YEELNYETMQ ESPAYTLTSV LADLGGLTGL WIGASVVSLL EIVTLIVFAT 
721:	QAYVRKRKGS ISAQSHHSVP VHRASRVSLN TLHKSSTTQS VKLSVMDIRS IKSIHSNHSS 
781:	KSKQSILIED LPPAIQEQSD DEEETTESSR TNGSCRYLAP GEDLPCLCKY HPDGSIRIMK 
841:	ALCPVHGYMV RRNYDYSVSN SEEEDAEDEV HREPEPFYSA PYEHRKK