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1.A.6.2.4
Motility and anesthetic-sensitive degenerin, UNC-8 (Uncoordinated protein-8) Na+ channel (regulated by UNC-1 (a mammalian stomatin homologue)). UNC-1 and UNC-8 are found in cholesterol/sphingolipid rafts together with UNC-24 (Bianchi, 2007; Sedensky et al., 2004)

Accession Number:Q21974
Protein Name:UNC-8
Length:777
Molecular Weight:89128.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

eggNOG: meNOG13575
HEGENOM: HBG383266
RefSeq: NP_501138.1   
Entrez Gene ID: 177494   
Pfam: PF00858   
KEGG: cel:R13A1.4   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005272 F:sodium channel activity
GO:0006814 P:sodium ion transport

References (1)

[1] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSPLLTWNLI CVSSRWYTIL CLKNKVKFWL GTRLVHEPES MESRSSPYIR PSPYAGGVHP 
61:	HFEEEDDRSK LHASALYSER RTSSRKSLRS QKIDYHTTTI KSLWFDFCAR TSSHGIPYVA 
121:	TSSFFGRYVW AALFMCMLMA FLLQTYWTMS EYLQYRTIIE MQLQFEAAAF PAATVCNLNA 
181:	FKYSELTQYE EIKEGFDYWE RVINARMMSD SMKPGGDILE AISVRKKRSK SRDQLLFPID 
241:	DEDLEGAVYQ PVFVRCTCMN MEQCVPNRNP LEVNASICMC FEDVTRGLIW PCYPTSVWTV 
301:	KKCSGCSISN TCPDPDGPNA SKQIAKHNSP LPCLCQSISH HCMVHPKDEI RWWNPNNYTV 
361:	YSVTEPPTTE ITETEEAFGL SDLKDAGAIT TQTKENLIFL VAALPRETRR NLSYTLNEFV 
421:	LRCSFNSKDC SMERDFKLHV DPEYGNCYTF NFNDSVELKN SRAGPMYGLR LLLNVHQSDY 
481:	MPTTEAAGVR LVVHEQDQEP FPDTFGYSAP TGFISSFGLK TKELHRLSAP WGNCSDTFRP 
541:	VPYIYNEHYS PEGCHRNCFQ LKVLEICGCG DPRFPLPSEE HRHCNAKSKI DRQCLSNLTS 
601:	DSGGYHHLHE QCECRQPCHE KVFETAYSAS AWPSQNFKIG TDCPAVSDIF NDTEACTEYY 
661:	RQNTAYIEIY YEQLNFESLK ETAGYTLVNL FSDFGGNIGL WIGFSVITFA EFAELFCEIC 
721:	KLMYFKGIVY VQKKMQGKEY TSSSLMHIDF LQRSPKKSQP GEDEVSTNES TKELMSK