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1.A.6.2.5
Mechanotransduction degenerin, DEL-1 (Bianchi, 2007).

Accession Number:Q19038
Protein Name:DEL-1
Length:664
Molecular Weight:75474.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

eggNOG: meNOG13575
HEGENOM: HBG388583
RefSeq: NP_510380.1   
Entrez Gene ID: 181534   
Pfam: PF00858   
KEGG: cel:E02H4.1   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005272 F:sodium channel activity
GO:0006814 P:sodium ion transport

References (1)

[1] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MARKYIDILK KSKMMLFQDV GKSFEDDSPC KEEAPKTQIQ HSVRDFCEQT TFHGVNMIFT 
61:	TSLYWVRFLW VVVSLVCICL CMYSFSHVKD KYDRKEKIVN VELVFESAPF PAITVCNLNP 
121:	FKNHLARSVP EISETLDAFH QAVVYSNDAT MDELSGRGRR SLNDGPSFKY LQYEPVYSDC 
181:	SCVPGRQECI AQTSAPRTLE NACICNYDRH DGSAWPCYSA QTWEKSICPE CNDIGFCNVP 
241:	NTTGSGNIPC YCQLEMGYCV FQPESRVRRI WEFQGNKIPE KGSPLRKEYM EQLTQLGYGN 
301:	MTDQVAITTQ AKEKMILKMS GLHPQRRAAL GYGKSELIKM CSFNGQQCNI DTEFKLHIDP 
361:	SFGNCYTFNA NPEKKLASSR AGPSYGLRLM MFVNSSDYLP TTEATGVRIA IHGKEECPFP 
421:	DTFGYSAPTG VISSFGISLR NINRLPQPYG NCLQKDNPQS RSIYKGYKYE PEGCFRSCYQ 
481:	YRIIAKCGCA DPRYPKPWKR SAWCDSTNTT TLNCLTTEGA KLSTKENQKH CKCIQPCQQD 
541:	QYTTTYSAAK WPSGSIQTSC DNHSKDCNSY LREHAAMIEI YYEQMSYEIL RESESYSWFN 
601:	LMADMGGQAG LFLGASIMSV IEFLFFAVRT LGIACKPRRW RQKTELLRAE ELNDAEKGVS 
661:	TNNN