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1.A.6.3.2
FMRFamide (peptide)-gated  sodium channel, FaNaC.  The charge on aspartate-552 in TMS2 influcences the gating properties and potency of the channel (Kodani and Furukawa 2010; Kodani and Furukawa 2014).  The FMRFamide-evoked current through AkFaNaC was depressed 2-3-fold by millimolar (1.8 mM) Ca2+ (Fujimoto et al. 2017). Both D552 and D556 were indispensable for the sensitivity of FaNaC to millimolar Ca2+. The Ca2+-sensitive gating was recapitulated by an allosteric model in which Ca2+-bound channels are more difficult to open. The desensitization of FaNaC was also inhibited by Ca2+ (Fujimoto et al. 2017).

Accession Number:Q4H3X6
Protein Name:FMRFamide-gated Na+ channel
Length:653
Molecular Weight:73978.00
Species:Aplysia kurodai (Kuroda's sea hare) [6501]
Number of TMSs:2
Substrate Na+

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FASTA formatted sequence
1:	MLGRGERIKP YHFRDSSADH MKYTSVAAKS GMVPEHRYTM VRSRHHGRHH HHHSYQEYNT 
61:	QRSAISLIAE LGSESNAHGL AKIVTSRDTK RKVIWALMVI IGFTAATLQL SLLVRKYLQF 
121:	QVVELSEIKD SMPVEYPSVT ICNIEPISLR KIRKAYNKNE SQNLKDWLNF TQTFHFKDMS 
181:	FMNSIRAFYE NLGTDAKKIS HDLRDLLIHC RFNREECTTE NFTSSFDGNY FNCFTFNGGQ 
241:	LRDQLQMHAT GPENGLSLII SIEKDEPLPG TYGVYNFENN ILHSAGVRVV VHAPGSMPSP 
301:	VDHGFDIPPG YSSSVGLKAL LHTRLSEPYG NCTEDSLEGI QTYRNTFFAC LQLCKQRRLI 
361:	RECKCKSSAL PDLSVENITF CGVIPDWKDI RRNVTGEYKM NQTIPTISLA CEARVQKQLN 
421:	NDRSYETDCG CYQPCSETSY LKSVSLSYWP LEFYQLSALE RFFSQKHPTD QQHFMKIAQD 
481:	FLSRLAHPQQ QALARNNSHD KDILTTSYSL SEKEMAKEAS DLIRQNLLRL NIYLEDLSVV 
541:	EYRQLPAYGL ADLFADIGGT LGLWMGISVL TIMELMELII RLFALIFNAE REVPKAPMHN 
601:	SNNGGSGGGD GSGGQHNFAN GDVEHERDTH FPDLGSSDFD FRRGGGIGAE SPV