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1.A.6.4.1
Ripped pocket (Rpk) fly gonad-specific Na+ channel (amiloride-sensitive) (Adams et al., 1998).

Accession Number:O46342
Protein Name:RPK aka DGNAC1 aka CG1058
Length:562
Molecular Weight:64768.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

eggNOG: inNOG06317
RefSeq: NP_524225.1   
Entrez Gene ID: 40580   
Pfam: PF00858   
KEGG: dme:Dmel_CG1058   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005272 F:sodium channel activity
GO:0006814 P:sodium ion transport

References (5)

[1] “Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons.”  Adams C.M.et.al.   9425162
[2] “A new member of the amiloride-sensitive sodium channel family in Drosophila melanogaster peripheral nervous system.”  Darboux I.et.al.   9600094
[3] “dGNaC1, a gonad-specific amiloride-sensitive Na+ channel.”  Darboux I.et.al.   9545267
[4] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[5] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTISDSELDS SKGIDLTFRR RRKAGSVACE GFITTYHEYC RNTSIHGVQY LGEQERPFRE 
61:	RIFWLFVFLI SIYGCSTLIQ SAYTKWTETP VIVSFAEKST PVWNIPFPAV TVCSETKRVL 
121:	KQKGKETTYA DLYSQFSEDM RASRVFRPEN VSALEMEEFR TLLHVCNTQI IEEDIPLIAG 
181:	DDLDYFDVLQ RMLPQFDRYF FYCRWLSRFG ECETFFRKTL TEEGICYTFN GLRATEIYRD 
241:	DTYQYQHSGE PLEMENISSQ HTAWTLETGY ALDSDVETFP ARVLSAGARS GIFLALQSFK 
301:	QEVDYACRGP VQGFKVLLHA PDDVPQVSKQ FVRIPMGKEV LIAVKPNMIT MSSGIAEYHP 
361:	VRRQCFLSHE RSLRFFKVYT ESNCQLECLA NFTLTKCGCV KFSMPRNVDM PVCGEDKIHC 
421:	YDRAERELLV REFKRVKALN AGRENSRSVE SACNCMPACT SLVYNTEISQ ANFDLEEMLV 
481:	AEGDTEFLKE YPGSQMSRLS IYFKQSQFIT SKRSELYGMT EFLANCGGIF GLFMGFSILS 
541:	LVEMIYHFTL RLFTNLKRLV KG