TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.6.4.3
Putative Na+ channel 

Accession Number:O61365
Protein Name:Sodium channel protein Nach
Length:535
Molecular Weight:62330.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

eggNOG: NOG306929
Entrez Gene ID: 36864   
Pfam: PF00858   
KEGG: dme:Dmel_CG8178   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005272 F:sodium channel activity
GO:0035002 P:liquid clearance, open tracheal system

References (3)

[1] “Drosophila DEG/ENaC pickpocket genes are expressed in the tracheal system, where they may be involved in liquid clearance.”  Liu L.et.al.   12571352
[2] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[3] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MGHQEELKPE QVDLKVTPFV GYLRRTWSDF CATSSIHGLK YTRDEDTNKI VHLVWLLISV 
61:	VMFICAVVMA RTFYMDYRSS PTRMNVESDN TPVNRLYFPP VTICPDVLFN MQKSEAFLNT 
121:	LRLPKGAELR GILRKLHIFY GFMLDDERYS AEDIEQMEAL LFLNNLTIPE FVEHLRWNCD 
181:	EILYRCRFNG EIMDCSKIFQ LSKTFFGHCC SFNLRQKGWV NNKLNNLESF KVFHLNSLNF 
241:	TAQRAIGGLR YGLSVVVRYK DDNYDPLQSY SYGVKLLIQE ADAFPSAHSA AKFIAFNSET 
301:	FAAVRPQETF CSSAVKALII EERNCVFQNE FPMRYFSDYV YPNCELNCRV TNMVKFCGCH 
361:	TYFFDFNRTS DRICTFRDIP CLVDNFANII TRKKSTQCYC PLTCEHIDYD VQLTNFPLEL 
421:	NMPVADKFYS GLAKNDGVLH VFINSFSYRR LRRDLLSNMV TLVSNLGSAF SLFVGMSMLS 
481:	VVEIIYYFSV ILRKNYKLEC ETRSQMLHKK PKFAWPKAND THSKEQKSVF IIHKS