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1.A.60.1.1
Core protein Mu-1 (42aas; 1TMS) (Agosto et al., 2006). The reovirus myristoylated µ1N pore forming peptide derived from the N-terminus of the µ1 viral capsid protein (708aas). Permeability order: Cs+ > Rb+ > K+ > Na+ > Li+ (crystal structures are available for chains A-U).

Accession Number:P12397
Protein Name:Chain F
Length:708
Molecular Weight:76146.00
Species:Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) [10885]
Location1 / Topology2 / Orientation3: Virion1 / Lipid-anchor2
Substrate Cs+, Rb+, K+, Na+, Li+

Cross database links:

RefSeq: NP_694625.1   
Entrez Gene ID: 956464   
Pfam: PF05993   

Gene Ontology

GO:0044165 C:host cell endoplasmic reticulum
GO:0033650 C:host cell mitochondrion
GO:0020002 C:host cell plasma membrane
GO:0016020 C:membrane
GO:0019028 C:viral capsid
GO:0043498 F:cell surface binding
GO:0005515 F:protein binding
GO:0006915 P:apoptosis
GO:0009405 P:pathogenesis
GO:0019063 P:virion penetration into host cell

References (2)

[1] “Evolution of reovirus genes: a comparison of serotype 1, 2, and 3 M2 genome segments, which encode the major structural capsid protein mu 1C.”  Wiener J.R.et.al.   3354208
[2] “A carboxy-terminal fragment of protein mu 1/mu 1C is present in infectious subvirion particles of mammalian reoviruses and is proposed to have a role in penetration.”  Nibert M.L.et.al.   1328674

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGNASSIVQT INVTGDGNVF KPSAETSSTA VPSLSLSPGM LNPGGVPWIA IGDETSVTSP 
61:	GALRRMTSKD IPETAIINTD NSSGAVPSES ALVPYNDEPL VVVTEHAIAN FTKAEMALEF 
121:	NREFLDKLRV LSVSPKYSDL LTYVDCYVGV SARQALNNFQ KQVPVITPTR QTMYVDSIQA 
181:	ALKALEKWEI DLRVAQTLLP TNVPIGEVSC PMQSVVKLLD DQLPDDSLIR RYPKEAAVAL 
241:	AKRNGGIQWM DVSEGTVMNE AVNAVAASAL APSASAPPLE EKSKLTEQAM DLVTAAEPEI 
301:	IASLVPVPAP VFAIPPKPAD YNVRTLKIDE ATWLRMIPKT MNTPFQIQVT DNTGTSWHMN 
361:	LRGGTRVVNL DQIAPMRFVL DLGGKSYKET SWDPNGKKVG FIVFQSKIPF ELWTAASQIG 
421:	QATVVNYVQL YAEDSSFTAQ SIIATTSLAY NYEPEQLNKT DPEMNYYLLA AFIDSAAIST 
481:	SNMTQPDVWD ALLTMSPLSA GEVTVKGAVV SEVIPADLVG SYTPESLNAS LPNDAARCMI 
541:	DRASKIAEAI KIDDDAGPDE YSPNSVPIQG QLAISQLETG YGVRIFNPKG ILSKIASRAM 
601:	QAFIGDPSTI ITQAAPVLSD KNNWIALAQG VKTSLRTKSL SAGVKTAVSK LSSSESIQSW 
661:	TQGFLDKVST HFPAPKPDCP QSGDSGDGSA RRLKRDSYAG VVKRGYTR