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1.A.62.1.2
The homotrimeric monovalent cation channel, TRIC-B (TMEM38B; Mitsugumin-33B; 292 aas; 7 TMSs; DUF714 domain) (Yazawa et al., 2007). PK+:Na+ = 1.5; impermeable to divalent cations. Apparent subconductance openings provide most of the K+ flux when the SR membrane potential is close to zero (Matyjaszkiewicz et al. 2015).  Mutations give rise to osteogenesis imperfecta (OI) in humans, a group of clinically and genetically heterogeneous disorders characterized by decreased bone mass and recurrent bone fractures (Lv et al. 2016).

Accession Number:Q9DAV9
Protein Name:Transmembrane protein 38B aka TRIC-B
Length:292
Molecular Weight:32640.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate K+, Na+

Cross database links:

Genevestigator: Q9DAV9
eggNOG: roNOG13137
HEGENOM: HBG315839
RefSeq: NP_082329.1   
Entrez Gene ID: 52076   
Pfam: PF05197   
KEGG: mmu:52076   

Gene Ontology

GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane
GO:0005267 F:potassium channel activity
GO:0006813 P:potassium ion transport

References (4)

[1] “TRIC channels are essential for Ca2+ handling in intracellular stores.”  Yazawa M.et.al.   17611541
[2] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[3] “Lineage-specific biology revealed by a finished genome assembly of the mouse.”  Church D.M.et.al.   19468303
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEYPWDDLTL AFSRTSMFPF FDIAHYLVSV MALKQRPGAV AAAWNNPLAS WLSAMLHCFG 
61:	GGILSCMLLA ESPLKFLTNH TNILLASSIW YIVFFCPRDL VSQGYSYQPI QFLAAGMKEV 
121:	TRTWKIVGGV SDANSYYRNA WIVMIVVGWA RGAGGAVVTA CEQLLKGDWK PEGDEWLKMS 
181:	FPCKITLLGS IMFTFQHTRH LAISKHDLMF LYTIFLVTIK VTMMMTKDTA VTLTPFEDTL 
241:	TRMLFGRRQQ QQFSSSEKKT EVKPSSNGSA SSASKRGAEP SGGAKRHAKK ED