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1.A.62.1.3
TMEM38B/TRIC-B of 291 aas and 6 TMSs.  Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchrony with calcium release from intracellular stores.  Required for intracellular homeostasis and is responsible for a mild form of recessive osteogenesis imperfecta. TRIC-B is proposed to counterbalance IP3R-mediated Ca2+ release from intracellular stores (Cabral et al. 2016).

Accession Number:Q9NVV0
Protein Name:Trimeric intracellular cation channel type B
Length:291
Molecular Weight:32510.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Ca2+, K+

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDSPWDELAL AFSRTSMFPF FDIAHYLVSV MAVKRQPGAA ALAWKNPISS WFTAMLHCFG 
61:	GGILSCLLLA EPPLKFLANH TNILLASSIW YITFFCPHDL VSQGYSYLPV QLLASGMKEV 
121:	TRTWKIVGGV THANSYYKNG WIVMIAIGWA RGAGGTIITN FERLVKGDWK PEGDEWLKMS 
181:	YPAKVTLLGS VIFTFQHTQH LAISKHNLMF LYTIFIVATK ITMMTTQTST MTFAPFEDTL 
241:	SWMLFGWQQP FSSCEKKSEA KSPSNGVGSL ASKPVDVASD NVKKKHTKKN E