TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.64.2.1
Myelin and Lymphocyte Protein, MAL/VIP17 protein, a regulator of NKCC2 (2.A.30.1.1). It stabilizes kidney apical membranes, and facilitates sorting of proteins to these membranes (Carmosino et al., 2010). Like plasmolipin, it has 4 TMSs that align with those of plasmolipin.

Accession Number:Q28296
Protein Name:Myelin and lymphocyte protein
Length:153
Molecular Weight:16624.00
Species:Canis familiaris (Dog) [9615]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate ions

Cross database links:

eggNOG: maNOG19631
Entrez Gene ID: 403933   
Pfam: PF01284   
KEGG: cfa:403933   

Gene Ontology

GO:0016021 C:integral to membrane

References (1)

[1] “VIP17/MAL, a proteolipid in apical transport vesicles.”  Zacchetti D.et.al.   8549777

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MAPAAASGGS SLPSGFSVFT TFPDLLFIFE FIFGGLVWIL IASSLVPIPL VQGWVMFVSV 
61:	FCFMATTALL VLYIIGAHGG ENSWVTLDAA YHCIAALFYL SASVLEALAT IGMQEGYTYK 
121:	QYHENISAVV FSYVATLLYV VHAVFSLIRW KSS