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1.A.64.5.1
CKLF-like MARVEL transmembrane domain-containing protein 7, CMTM7 (175aas; 4 TMSs; Miyazaki et al., 2012). CMTM7 functions to link sIgM and BLNK in the plasma membrane, to recruit BLNK to the vicinity of Syk, and to initiate BLNK-mediated signal transduction (Miyazaki et al., 2012). No transport function is known.

Accession Number:Q96FZ5
Protein Name:CKLF-like MARVEL transmembrane domain-containing protein 7
Length:175
Molecular Weight:18834.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate ions

Cross database links:

Genevestigator: Q96FZ5
eggNOG: NOG296346
HEGENOM: HOG000111751
Entrez Gene ID: 112616   
Pfam: PF01284   
KEGG: hsa:112616   

Gene Ontology

GO:0005615 C:extracellular space
GO:0016021 C:integral to membrane
GO:0006935 P:chemotaxis

References (3)

[1] “Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation.”  Han W.et.al.   12782130
[2] “The DNA sequence, annotation and analysis of human chromosome 3.”  Muzny D.M.et.al.   16641997
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSHGAGLVRT TCSSGSALGP GAGAAQPSAS PLEGLLDLSY PRTHAALLKV AQMVTLLIAF 
61:	ICVRSSLWTN YSAYSYFEVV TICDLIMILA FYLVHLFRFY RVLTCISWPL SELLHYLIGT 
121:	LLLLIASIVA ASKSYNQSGL VAGAIFGFMA TFLCMASIWL SYKISCVTQS TDAAV