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1.A.64.5.4
CKLF-like MARVEL transmembrane domain-containing protein 8 of 343 aas and 4 TMSs, CMTM8. A short splice variant, CMTM8-v2, retains the ability to induce apoptosis via caspase-dependent and -independent pathways to inhibit cell growth and colony formation. CMTM8 and CMTM8-v2 display different expression profiles and distinct subcellular localization patterns, while operating via different mechanisms to induce apoptosis. CMTM8-v2 does not affect EGFR internalization, implying that the MARVEL domain and/or the cytosolic YXXPhi motifs are necessary for CMTM8 to accelerate ligand-induced EGFR internalization (Li et al. 2007).

Accession Number:R0LL85
Protein Name:CKLF-like MARVEL transmembrane domain-containing protein 8
Length:173
Molecular Weight:19539.00
Species:Anas platyrhynchos (Mallard) [8839]
Number of TMSs:4
Substrate ions

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FASTA formatted sequence
1:	QEQPPRPRSH TVTTTSSSFT ANLSASSSTL AYDREFLRTL PGLLMVAEIV LGLLVWTLIA 
61:	GTEYFLYPAF GWVMFVAVFY WVLTVFFLII YMTMTYTRIP QVPWTTVGLC FNGSAFILYL 
121:	IAAIVDASSV TKELDSHNYN SWAASSFFAF VVTSCYAGNT YFSFISWRSR TLQ