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1.A.65.1.1
The E protein viroporin

Accession Number:P0C2R0
Protein Name:E protein viroporin
Length:83
Molecular Weight:9667.00
Species:Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) [11142]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Virion membrane1 / Single-pass type III membrane protein2
Substrate small molecules

Cross database links:

RefSeq: NP_068673.1   
Entrez Gene ID: 1489755   
Pfam: PF02723   

Gene Ontology

GO:0044178 C:host cell Golgi membrane
GO:0016021 C:integral to membrane
GO:0019031 C:viral envelope
GO:0055036 C:virion membrane
GO:0006915 P:apoptosis

References (6)

[1] “Altered pathogenesis of a mutant of the murine coronavirus MHV-A59 is associated with a Q159L amino acid substitution in the spike protein.”  Leparc-Goffart I.et.al.   9426441
[2] “Release of coronavirus E protein in membrane vesicles from virus-infected cells and E protein-expressing cells.”  Maeda J.et.al.   10544100
[3] “Induction of apoptosis in murine coronavirus-infected cultured cells and demonstration of E protein as an apoptosis inducer.”  An S.et.al.   10438879
[4] “Characterization of the coronavirus mouse hepatitis virus strain A59 small membrane protein E.”  Raamsman M.J.et.al.   10666264
[5] “Membrane topology of coronavirus E protein.”  Maeda J.et.al.   11277690
[6] “Viroporin activity of murine hepatitis virus E protein.”  Madan V.et.al.   15963987

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFNLFLTDTV WYVGQIIFIF AVCLMVTIIV VAFLASIKLC IQLCGLCNTL VLSPSIYLYD 
61:	RSKQLYKYYN EEMRLPLLEV DDI