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1.A.65.1.2
The SARS coronavirus pore-forming envelope (E) protein (76 aas) forms a pentameric pore (Torres et al. 2006) that binds amantadine (Torres et al., 2007). A single polar residue and distinct membrane topologies impact its function (Ruch and Machamer, 2012).  E protein ion channel (IC) activity is specifically correlated with enhanced pulmonary damage, edema accumulation and death.  Calcium ions together with pH modulated E protein pore charge and selectivity (Nieto-Torres et al. 2015). There is a single transmembrane domain in E, suggesting an allosteric interaction between extramembrane and transmembrane domains (To et al. 2016).

Accession Number:Q19QW7
Protein Name:E protein
Length:76
Molecular Weight:8361.00
Species:Human SARS coronavirus (SARS-CoV) [227859]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate ions and small molecules

Cross database links:

Pfam: PF02723   

Gene Ontology

GO:0016020 C:membrane

References (2)

[1] “A Mouse-Adapted SARS-Coronavirus Causes Disease and Mortality in BALB/c Mice.”  Roberts A.et.al.   17222058
[2] “The SR-rich motif in SARS-CoV nucleocapsid protein is important for virus replication.”  Tylor S.et.al.   19370068

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FASTA formatted sequence
1:	MYSFVSEETG TLIVNSVLLF LAFVVFLLVT LAILTALRLC AYCCNIVNVS LVKPTVYVYS 
61:	RVKNLNSSEG VPDLLV