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1.A.69.3.2
Gustatory receptor 43a isoform A.  Functions as a narrowly tuned fructose receptor in taste neurons (Miyamoto et al. 2012), being both necessary and sufficient to sense hemolymph fructose.

Accession Number:Q9V4K2
Protein Name:Putative gustatory receptor 43a
Length:427
Molecular Weight:47573.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

eggNOG: NOG40165
DIP: DIP-22568N
Entrez Gene ID: 35655   
Pfam: PF08395   
KEGG: dme:Dmel_CG1712   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008527 F:taste receptor activity

References (4)

[1] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[2] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[3] “Candidate taste receptors in Drosophila.”  Clyne P.J.et.al.   10710312
[4] “Spatially restricted expression of candidate taste receptors in the Drosophila gustatory system.”  Dunipace L.et.al.   11516643

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEISQPSIGI FYISKVLALA PYATVRNSKG RVEIGRSWLF TVYSATLTVV MVFLTYRGLL 
61:	FDANSEIPVR MKSATSKVVT ALDVSVVVMA IVSGVYCGLF SLNDTLELND RLNKIDNTLN 
121:	AYNNFRRDRW RALGMAAVSL LAISILVGLD VGTWMRIAQD MNIAQSDTEL NVHWYIPFYS 
181:	LYFILTGLQV NIANTAYGLG RRFGRLNRML SSSFLAENNA TSAIKPQKVS TVKNVSVNRP 
241:	AMPSALHASL TKLNGETLPS EAAAKNKGLL LKSLADSHES LGKCVHLLSN SFGIAVLFIL 
301:	VSCLLHLVAT AYFLFLELLS KRDNGYLWVQ MLWICFHFLR LLMVVEPCHL AARESRKTIQ 
361:	IVCEIERKVH EPILAEAVKK FWQQLLVVDA DFSACGLCRV NRTILTSFAS AIATYLVILI 
421:	QFQRTNG