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Accession Number: | Q99572 |
Protein Name: | P2X purinoceptor 7 aka ATP receptor aka P2X7 aka Purinergic receptor aka P2Z receptor |
Length: | 595 |
Molecular Weight: | 68586.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 3 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | sodium ions, calcium ions, inorganic cations |
Cross database links:
Genevestigator: | Q99572 |
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eggNOG: | prNOG13847 |
HEGENOM: | HBG713324 |
RefSeq: | NP_002553.2 |
Entrez Gene ID: | 5027 |
Pfam: | PF00864 |
OMIM: |
602566 gene |
KEGG: | hsa:5027 |
Gene Ontology
GO:0032059
C:bleb
GO:0005737
C:cytoplasm
GO:0005887
C:integral to plasma membrane
GO:0005524
F:ATP binding
GO:0004931
F:extracellular ATP-gated cation channel acti...
GO:0001530
F:lipopolysaccharide binding
GO:0042803
F:protein homodimerization activity
GO:0001614
F:purinergic nucleotide receptor activity
GO:0005102
F:receptor binding
GO:0032060
P:bleb assembly
GO:0007166
P:cell surface receptor linked signaling pathway
GO:0045779
P:negative regulation of bone resorption
GO:0043409
P:negative regulation of MAPKKK cascade
GO:0046931
P:pore complex assembly
GO:0030501
P:positive regulation of bone mineralization
GO:0010524
P:positive regulation of calcium ion transpor...
GO:0045919
P:positive regulation of cytolysis
GO:0051495
P:positive regulation of cytoskeleton organiz...
GO:0050718
P:positive regulation of interleukin-1 beta s...
GO:0051709
P:regulation of killing of cells of another o...
GO:0002028
P:regulation of sodium ion transport
GO:0033198
P:response to ATP
GO:0019233
P:sensory perception of pain
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References (7)[1] “The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA.” Rassendren F.et.al. 9038151 [2] “Gene structure and chromosomal localization of the human P2X7 receptor.” Buell G.N.et.al. 9826911 [3] “The finished DNA sequence of human chromosome 12.” Scherer S.E.et.al. 16541075 |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MPACCSCSDV FQYETNKVTR IQSMNYGTIK WFFHVIIFSY VCFALVSDKL YQRKEPVISS 61: VHTKVKGIAE VKEEIVENGV KKLVHSVFDT ADYTFPLQGN SFFVMTNFLK TEGQEQRLCP 121: EYPTRRTLCS SDRGCKKGWM DPQSKGIQTG RCVVYEGNQK TCEVSAWCPI EAVEEAPRPA 181: LLNSAENFTV LIKNNIDFPG HNYTTRNILP GLNITCTFHK TQNPQCPIFR LGDIFRETGD 241: NFSDVAIQGG IMGIEIYWDC NLDRWFHHCR PKYSFRRLDD KTTNVSLYPG YNFRYAKYYK 301: ENNVEKRTLI KVFGIRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLAAVF IDFLIDTYSS 361: NCCRSHIYPW CKCCQPCVVN EYYYRKKCES IVEPKPTLKY VSFVDESHIR MVNQQLLGRS 421: LQDVKGQEVP RPAMDFTDLS RLPLALHDTP PIPGQPEEIQ LLRKEATPRS RDSPVWCQCG 481: SCLPSQLPES HRCLEELCCR KKPGACITTS ELFRKLVLSR HVLQFLLLYQ EPLLALDVDS 541: TNSRLRHCAY RCYATWRFGS QDMADFANLP SCCRWRIRKE FPKSEGQYSG FKSPY