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1.A.71.2.1
Growth-associated protein 43 (GAP-43); Neuromodulin isoform 2, neural phosphoprotein B-50; A major component of the motile "growth cones" that forms the tips of elongated axons. Binds calmodulin with high affinity -Ca2+, low affinity +Ca2+. (Reported not to form channels; (Ostroumova et al., 2011)).

Accession Number:P17677
Protein Name:Neuromodulin
Length:238
Molecular Weight:24803.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Cell membrane1 / Peripheral membrane protein2 / Cytoplasmic side3
Substrate Ca2+

Cross database links:

Genevestigator: P17677
eggNOG: prNOG14568
DIP: DIP-452N
Entrez Gene ID: 2596   
Pfam: PF00612    PF06614    PF10580   
KEGG: hsa:2596   

Gene Ontology

GO:0030054 C:cell junction
GO:0032584 C:growth cone membrane
GO:0045202 C:synapse
GO:0005516 F:calmodulin binding
GO:0007205 P:activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
GO:0030154 P:cell differentiation
GO:0007399 P:nervous system development
GO:0040008 P:regulation of growth
GO:0009611 P:response to wounding

References (5)

[1] “Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human.”  Kosik K.S.et.al.   3272162
[2] “Cloning of human GAP-43: growth association and ischemic resurgence.”  Ng S.-C.et.al.   3272163
[3] “Structure of the human gene for the neural phosphoprotein B-50 (GAP-43).”  Nielander H.B.et.al.   8231732
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Characterization of single-nucleotide polymorphisms in coding regions of human genes.”  Cargill M.et.al.   10391209

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLCCMRRTKQ VEKNDDDQKI EQDGIKPEDK AHKAATKIQA SFRGHITRKK LKGEKKDDVQ 
61:	AAEAEANKKD EAPVADGVEK KGEGTTTAEA APATGSKPDE PGKAGETPSE EKKGEGDAAT 
121:	EQAAPQAPAS SEEKAGSAET ESATKASTDN SPSSKAEDAP AKEEPKQADV PAAVTAAAAT 
181:	TPAAEDAAAK ATAQPPTETG ESSQAEENIE AVDETKPKES ARQDEGKEEE PEADQEHA